LIPID NANOPARTICLES HAVING CELL DIRECTIVITY

WIPO Patent Application WO/2023/054243

A1

The present invention provides lipid nanoparticles containing a ligand having cell directivity bonded to an activated PEG lipid and an ionic lipid (the definitions of the symbols in the formula are as described in the description) represented by formula (1).

TANGE KOTA (JP)
YOSHIOKA HIROKI (JP)
NAKAI YUTA (JP)
AKITA HIDETAKA (JP)
SAKURAI YU (JP)
TANAKA HIROKI (JP)
IWASAKI KOKI (JP)

PCT/JP2022/035639

April 06, 2023

September 26, 2022

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NOF CORP (JP)
UNIV CHIBA NAT UNIV CORP (JP)

A61K9/127; A61K9/16; A61K31/7088; A61K47/20; A61K47/22; A61K47/24; A61K47/28; A61K47/34; A61K47/42; A61K48/00; A61P35/00; A61P43/00

WO2019188867A1

2019-10-03

JP2008239631A	2008-10-09
JP2008536944A	2008-09-11
JP2000510825A	2000-08-22

BIANCHINI FRANCESCA; DE SANTIS AUGUSTA; PORTIOLI ELISABETTA; RUSSO KRAUSS IRENE; BATTISTINI LUCIA; CURTI CLAUDIO; PEPPICELLI SILVI: "Integrin-targeted AmpRGD sunitinib liposomes as integrated antiangiogenic tools", NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY, AND MEDICINE, vol. 18, 1 January 1900 (1900-01-01), AMSTERDAM, NL, pages 135 - 145, XP085713680, ISSN: 1549-9634, DOI: 10.1016/j.nano.2019.02.015
WANG YAZHE, XIE YING, LI JING, PENG ZHENG-HONG, SHEININ YURI, ZHOU JIANPING, OUPICKÝ DAVID: "Tumor-Penetrating Nanoparticles for Enhanced Anticancer Activity of Combined Photodynamic and Hypoxia-Activated Therapy", ACS NANO, vol. 11, no. 2, 28 February 2017 (2017-02-28), US , pages 2227 - 2238, XP093054368, ISSN: 1936-0851, DOI: 10.1021/acsnano.6b08731

TAKASHIMA, Hajime (JP)

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