Title:
LIPID NANOPARTICLES
Document Type and Number:
WIPO Patent Application WO/2023/188830
Kind Code:
A1
Abstract:
The present invention provides lipid nanoparticles each containing a pH-sensitive cationic lipid represented by formula (I) [wherein a represents an integer of 3 to 5; b represents 0 or 1; R1 and R2 each independently represent a group represented by general formula (A) (wherein R11 and R12 each independently represent a linear or branched C1-15 alkyl group; c represents an integer of 1 to 7: and e represents an integer of 4 to 12); and X represents a group represented by general formula (B) (wherein d represents an integer of 0 to 3; and R3 and R4 each independently represent a C1-4 alkyl group or a C2-4 alkenyl group, in which R3 and R4 may be bonded to each other to form a 5- to 7-membered nonaromatic hetero ring) or a 5- to 7-membered nonaromatic hetero ring group]. (R1)(R2)C(OH)-(CH2)a-(O-CO)b-X (I) (R11)(R12)HC-(CH2)c-(CO-O)-(CH2)e-(A)
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Inventors:
SATO YUSUKE (JP)
HARASHIMA HIDEYOSHI (JP)
ONUMA HARUNO (JP)
HARASHIMA HIDEYOSHI (JP)
ONUMA HARUNO (JP)
Application Number:
PCT/JP2023/003844
Publication Date:
October 05, 2023
Filing Date:
February 06, 2023
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
A61K47/18; A61K9/127; A61K9/51; A61K31/7088; A61K31/7105; A61K31/713; A61K48/00; A61P1/16; A61P43/00; C07C219/06; C12N15/09; C12N15/113; C12N15/88
Domestic Patent References:
| WO2020241679A1 | 2020-12-03 | |||
| WO2018230710A1 | 2018-12-20 |
Other References:
SATO, YUSUKE ET AL.: "II-PM-24 In vivo Gene Knockout Using CRISPR/Cas9 RNP-Equipped Lipid Nanoparticles", PROCEEDINGS OF THE 38TH ANNUAL MEETING OF THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM (DDS); ONLINE; JUNE 29-30, 2022, vol. 38, 10 June 2022 (2022-06-10) - 30 June 2022 (2022-06-30), pages 122, XP009549855
SATO, YUSUKE ET AL.: "2-C-17 Development of CRISPR/Cas Protein-Equipped Lipid Nanoparticles", PROCEEDINGS OF THE 36TH ANNUAL MEETING OF THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM (DDS); AUGUST 28-29, 2020, vol. 36, 10 August 2020 (2020-08-10) - 29 August 2020 (2020-08-29), pages 162, XP009549854
HARUNO ONUMA, YUICHI SUZUKI, YUSUKE SATO, HIDEYOSHI HARASHIMA: "1P-39: Highly efficient genome editing by lipid nanoparticles with Cas RNPs", PROCEEDINGS OF THE 6TH ANNUAL MEETING OF THE NUCLEIC ACIDS THERAPEUTICS SOCIETY OF JAPAN; JUNE 27TH TO 29TH, 2021, NUCLEIC ACIDS THERAPEUTICS SOCIETY OF JAPAN, JP, 1 January 2021 (2021-01-01) - 29 June 2021 (2021-06-29), JP, pages 121, XP009550137
SUZUKI YUICHI, ONUMA HARUNO, SATO RISA, SATO YUSUKE, HASHIBA AKARI, MAEKI MASATOSHI, TOKESHI MANABU, KAYESH MOHAMMAD ENAMUL HOQUE,: "Lipid nanoparticles loaded with ribonucleoprotein–oligonucleotide complexes synthesized using a microfluidic device exhibit robust genome editing and hepatitis B virus inhibition", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 330, 1 February 2021 (2021-02-01), AMSTERDAM, NL , pages 61 - 71, XP093097003, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2020.12.013
SATO, YUSUKE ET AL.: "2-C-17 Development of CRISPR/Cas Protein-Equipped Lipid Nanoparticles", PROCEEDINGS OF THE 36TH ANNUAL MEETING OF THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM (DDS); AUGUST 28-29, 2020, vol. 36, 10 August 2020 (2020-08-10) - 29 August 2020 (2020-08-29), pages 162, XP009549854
HARUNO ONUMA, YUICHI SUZUKI, YUSUKE SATO, HIDEYOSHI HARASHIMA: "1P-39: Highly efficient genome editing by lipid nanoparticles with Cas RNPs", PROCEEDINGS OF THE 6TH ANNUAL MEETING OF THE NUCLEIC ACIDS THERAPEUTICS SOCIETY OF JAPAN; JUNE 27TH TO 29TH, 2021, NUCLEIC ACIDS THERAPEUTICS SOCIETY OF JAPAN, JP, 1 January 2021 (2021-01-01) - 29 June 2021 (2021-06-29), JP, pages 121, XP009550137
SUZUKI YUICHI, ONUMA HARUNO, SATO RISA, SATO YUSUKE, HASHIBA AKARI, MAEKI MASATOSHI, TOKESHI MANABU, KAYESH MOHAMMAD ENAMUL HOQUE,: "Lipid nanoparticles loaded with ribonucleoprotein–oligonucleotide complexes synthesized using a microfluidic device exhibit robust genome editing and hepatitis B virus inhibition", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 330, 1 February 2021 (2021-02-01), AMSTERDAM, NL , pages 61 - 71, XP093097003, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2020.12.013
Attorney, Agent or Firm:
NISHIZAWA Kazuyoshi et al. (JP)
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