Title:
LIPOSOMAL SYSTEM AND METHOD OF USING SAME
Document Type and Number:
WIPO Patent Application WO2004033483
Kind Code:
A3
Abstract:
Liposomal systems formed from a peptide having a ubiquitinatable region and an antigenic region, a pH-sensitive liposomal carrier; and a bilayer-associated adjuvant, such as MPL are useful as vaccine compositions. These compositions are surprisingly effective in inducing an in vivo immune response to the antigen corresponding to the antigenic region.
Inventors:
TURK MARY JO (US)
GUEVARA JOSE ALEJANDRO (US)
HOUGHTON ALAN (US)
GUEVARA JOSE ALEJANDRO (US)
HOUGHTON ALAN (US)
Application Number:
PCT/US2003/031800
Publication Date:
June 09, 2005
Filing Date:
October 06, 2003
Export Citation:
Assignee:
SLOAN KETTERING INST CANCER (US)
TURK MARY JO (US)
GUEVARA JOSE ALEJANDRO (US)
HOUGHTON ALAN (US)
TURK MARY JO (US)
GUEVARA JOSE ALEJANDRO (US)
HOUGHTON ALAN (US)
International Classes:
A61K9/127; A61K39/00; A61K39/39; C07K14/00; C12N11/00; C07K; (IPC1-7): C12N11/00; C07K14/00
Other References:
ALVING ET AL: "Liposomes as carriers of peptide induction of antibodies and cytoxic T lymphocytes to conjugated and unconjugated peptides", IMMUNOL REV, vol. 145, June 1995 (1995-06-01), pages 5 - 31, XP000882591
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