Title:
LIPOSOME COMPRISING AT LEAST ONE CHOLESTEROL DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2013/026989
Kind Code:
A3
Abstract:
The present invention relates to a novel galenic form of cholesterol derivative. More particularly, the invention relates to liposomes comprising at least one cholesterol derivative and to compositions comprising said liposomes.
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Inventors:
CHAIMBAULT CORINNE (FR)
MICHAUD MAGALI (FR)
BERNA PATRICK (FR)
SCHALLER SOPHIE (FR)
BASSISSI FIRAS (FR)
EASTMAN SIMON (CA)
MICHAUD MAGALI (FR)
BERNA PATRICK (FR)
SCHALLER SOPHIE (FR)
BASSISSI FIRAS (FR)
EASTMAN SIMON (CA)
Application Number:
PCT/FR2012/051924
Publication Date:
August 08, 2013
Filing Date:
August 22, 2012
Export Citation:
Assignee:
TROPHOS (FR)
CHAIMBAULT CORINNE (FR)
MICHAUD MAGALI (FR)
BERNA PATRICK (FR)
SCHALLER SOPHIE (FR)
BASSISSI FIRAS (FR)
EASTMAN SIMON (CA)
CHAIMBAULT CORINNE (FR)
MICHAUD MAGALI (FR)
BERNA PATRICK (FR)
SCHALLER SOPHIE (FR)
BASSISSI FIRAS (FR)
EASTMAN SIMON (CA)
International Classes:
A61K31/575; A61K9/127; A61K31/685; A61P43/00
Domestic Patent References:
| WO1999013816A2 | 1999-03-25 | |||
| WO2006027454A1 | 2006-03-16 | |||
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Foreign References:
| US6143321A | 2000-11-07 | |||
| FR2650181A1 | 1991-02-01 | |||
| GB2013087A | 1979-08-08 |
Other References:
DATABASE WPI Week 201018, Derwent World Patents Index; AN 2010-C10744, XP002672816
SCHALLER SOPHIE ET AL: "TRO40303, a New Cardioprotective Compound, Inhibits Mitochondrial Permeability Transition", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 333, no. 3, June 2010 (2010-06-01), pages 696 - 706 URL, XP007920460, ISSN: 0022-3565
NAKAGAWA Y ET AL: "Transfer of steroids and alpha-tocopherol between liposomal membranes.", JOURNAL OF BIOCHEMISTRY FEB 1980 LNKD- PUBMED:6892636, vol. 87, no. 2, February 1980 (1980-02-01), pages 497 - 502, XP002686453, ISSN: 0021-924X
DEMEL R A ET AL: "The effect of sterol structure on the permeability of lipomes to glucose, glycerol and Rb<+>", BIOCHIMICA ET BIOPHYSICA ACTA. BIOMEMBRANES, AMSTERDAM, NL, vol. 255, no. 1, 17 January 1972 (1972-01-17), pages 321 - 330, XP023350900, ISSN: 0005-2736, [retrieved on 19720117], DOI: 10.1016/0005-2736(72)90031-4
RAMSAMMY L S ET AL: "Association of cholestanol and cholestanone with lysophosphatidylcholine", CHEMISTRY AND PHYSICS OF LIPIDS, LIMERICK, IR, vol. 34, no. 2, 1 February 1984 (1984-02-01), pages 127 - 138, XP025198071, ISSN: 0009-3084, [retrieved on 19840201], DOI: 10.1016/0009-3084(84)90038-0
DEMEL R A ET AL: "Structural requirements of sterols for the interaction with lecithin at the air-water interface", BIOCHIMICA ET BIOPHYSICA ACTA. BIOMEMBRANES, AMSTERDAM, NL, vol. 255, no. 1, 17 January 1972 (1972-01-17), pages 311 - 320, XP023350899, ISSN: 0005-2736, [retrieved on 19720117], DOI: 10.1016/0005-2736(72)90030-2
MAERKER, G. ET AL: "A-ring oxidation products from .gamma.-irradiation of cholesterol in liposomes", JOURNAL OF THE AMERICAN OIL CHEMISTS' SOCIETY , 70(3), 255-9 CODEN: JAOCA7; ISSN: 0003-021X, vol. 70, no. 3, 1993 - 1993, pages 255 - 259, XP009166580
MARTIN LEE J: "Olesoxime, a cholesterol-like neuroprotectant for the potential treatment of amyotrophic lateral sclerosis.", IDRUGS : THE INVESTIGATIONAL DRUGS JOURNAL AUG 2010, vol. 13, no. 8, August 2010 (2010-08-01), pages 568 - 580, XP007921500, ISSN: 2040-3410
SCHALLER SOPHIE ET AL: "TRO40303, a New Cardioprotective Compound, Inhibits Mitochondrial Permeability Transition", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 333, no. 3, June 2010 (2010-06-01), pages 696 - 706 URL, XP007920460, ISSN: 0022-3565
NAKAGAWA Y ET AL: "Transfer of steroids and alpha-tocopherol between liposomal membranes.", JOURNAL OF BIOCHEMISTRY FEB 1980 LNKD- PUBMED:6892636, vol. 87, no. 2, February 1980 (1980-02-01), pages 497 - 502, XP002686453, ISSN: 0021-924X
DEMEL R A ET AL: "The effect of sterol structure on the permeability of lipomes to glucose, glycerol and Rb<+>", BIOCHIMICA ET BIOPHYSICA ACTA. BIOMEMBRANES, AMSTERDAM, NL, vol. 255, no. 1, 17 January 1972 (1972-01-17), pages 321 - 330, XP023350900, ISSN: 0005-2736, [retrieved on 19720117], DOI: 10.1016/0005-2736(72)90031-4
RAMSAMMY L S ET AL: "Association of cholestanol and cholestanone with lysophosphatidylcholine", CHEMISTRY AND PHYSICS OF LIPIDS, LIMERICK, IR, vol. 34, no. 2, 1 February 1984 (1984-02-01), pages 127 - 138, XP025198071, ISSN: 0009-3084, [retrieved on 19840201], DOI: 10.1016/0009-3084(84)90038-0
DEMEL R A ET AL: "Structural requirements of sterols for the interaction with lecithin at the air-water interface", BIOCHIMICA ET BIOPHYSICA ACTA. BIOMEMBRANES, AMSTERDAM, NL, vol. 255, no. 1, 17 January 1972 (1972-01-17), pages 311 - 320, XP023350899, ISSN: 0005-2736, [retrieved on 19720117], DOI: 10.1016/0005-2736(72)90030-2
MAERKER, G. ET AL: "A-ring oxidation products from .gamma.-irradiation of cholesterol in liposomes", JOURNAL OF THE AMERICAN OIL CHEMISTS' SOCIETY , 70(3), 255-9 CODEN: JAOCA7; ISSN: 0003-021X, vol. 70, no. 3, 1993 - 1993, pages 255 - 259, XP009166580
MARTIN LEE J: "Olesoxime, a cholesterol-like neuroprotectant for the potential treatment of amyotrophic lateral sclerosis.", IDRUGS : THE INVESTIGATIONAL DRUGS JOURNAL AUG 2010, vol. 13, no. 8, August 2010 (2010-08-01), pages 568 - 580, XP007921500, ISSN: 2040-3410
Attorney, Agent or Firm:
SANTARELLI (Marseille Cedex 6, FR)
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