Title:
LIPOSOME FOR DELIVERING TAXANE-BASED DRUG AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2017/052255
Kind Code:
A1
Abstract:
The present invention relates to a liposome for delivering a taxane-based drug and a preparation method therefor. The liposome of the present invention has effects of prolonging the residence time of the liposome in blood by the PEGylation of the liposome to thereby increase the residence time in the blood, reducing a particle size by using an oil, improving storage stability by delaying precipitation of the drug, allowing for filter sterilization to thereby permit an intravenous injection thereof.
Inventors:
LIM SOO JEONG (KR)
HONG SOON SEOK (KR)
HONG SOON SEOK (KR)
Application Number:
PCT/KR2016/010633
Publication Date:
March 30, 2017
Filing Date:
September 23, 2016
Export Citation:
Assignee:
UNIV SEJONG IND ACAD COOP FOUND (KR)
International Classes:
A61K9/127; A61K9/00; A61K31/337; A61K47/14; A61K47/28; A61K47/44
Foreign References:
| KR20140017486A | 2014-02-11 | |||
| KR20040082590A | 2004-09-30 |
Other References:
CROSASSO, P. ET AL.: "Preparation, Characterization and Properties of Sterically Stabilized Paditaxel-containing Liposomes", JOURNAL OF CONTROLLED RELEASE, vol. 63, no. 1, 2000, pages 19 - 30
HONG, S. -S. ET AL.: "Effects of Triglycerides on the Hydrophobic Drug Loading Capacity of Saturated Phosphatidyleholine-based Liposomes", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 483, February 2015 (2015-02-01), pages 142 - 150
HONG, S. -S. ET AL.: "Development of Paclitaxel-loaded Liposomal Nanocarrier Stabilized by Triglyceride Incorporation", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 11, 6 September 2016 (2016-09-06), pages 4465 - 4477
HONG, S. -S. ET AL.: "Effects of Triglycerides on the Hydrophobic Drug Loading Capacity of Saturated Phosphatidyleholine-based Liposomes", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 483, February 2015 (2015-02-01), pages 142 - 150
HONG, S. -S. ET AL.: "Development of Paclitaxel-loaded Liposomal Nanocarrier Stabilized by Triglyceride Incorporation", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 11, 6 September 2016 (2016-09-06), pages 4465 - 4477
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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