Title:
LIPOSOME FORMULATION COMPRISING AN ANTI-TUMOUR ACTIVE SUBSTANCE, METHOD FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING IT
Document Type and Number:
WIPO Patent Application WO/2012/117385
Kind Code:
A3
Abstract:
The subject of the present invention is a liposomal formulation containing an anti-tumour compound characterised in that it contains the active compound encapsulated in liposome vesicles forming a composition of lipid components in the ratio of 1 part by mass of the active compound per 5 parts by mass of the lipid components, preferably 1 part by mass of the active compound per 5 parts by mass of the lipid components as well as a vitamin or a derivative thereof, a method of producing it as well as composition containing the said formulation.
Inventors:
GUBERNATOR JERZY (PL)
KOZUBEK ARKADIUSZ (PL)
PADUSZYNSKI PIOTR (PL)
KOZUBEK ARKADIUSZ (PL)
PADUSZYNSKI PIOTR (PL)
Application Number:
PCT/IB2012/051014
Publication Date:
February 28, 2013
Filing Date:
March 03, 2012
Export Citation:
Assignee:
WROCLAWSKIE CT BADAN EIT & SP Z O O (PL)
GUBERNATOR JERZY (PL)
KOZUBEK ARKADIUSZ (PL)
PADUSZYNSKI PIOTR (PL)
GUBERNATOR JERZY (PL)
KOZUBEK ARKADIUSZ (PL)
PADUSZYNSKI PIOTR (PL)
International Classes:
A61K31/375; A61K9/127; A61K31/519; A61K45/06
Foreign References:
| US6146659A | 2000-11-14 | |||
| US5648090A | 1997-07-15 | |||
| EP0160286A2 | 1985-11-06 |
Other References:
RIVERA E: "Liposomal anthracyclines in metastatic breast cancer: Clinical update", THE ONCOLOGIST, ALPHAMED PRESS, US, vol. 8, no. SUPPL. 2, 1 August 2003 (2003-08-01), pages 3 - 9, XP008117303, ISSN: 1083-7159, DOI: 10.1634/THEONCOLOGIST.8-SUPPL_2-3
PEREZ-SOLER R ET AL: "THE USE OF LIPOSOMES AS CARRIERS OF LIPOPHILIC ANTHRACYCLINE ANTIBIOTICS", JOURNAL OF LIPOSOME RESEARCH, TAYLOR & FRANCIS, PHILADELPHIA, PA, US, vol. 4, no. 1, 1 January 1994 (1994-01-01), pages 555 - 573, XP000564587, ISSN: 0898-2104
KIRBY C J ET AL: "STABILIZATION OF ASCORBIC ACID BY MICROENCAPSULATION IN LIPOSOMES", INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, BLACKWELL SCIENTIFIC PUBLICATIONS, OXFORD, GB, vol. 26, no. 5, 1 January 1991 (1991-01-01), pages 437 - 449, XP009045590, ISSN: 0950-5423
PEREZ-SOLER R ET AL: "THE USE OF LIPOSOMES AS CARRIERS OF LIPOPHILIC ANTHRACYCLINE ANTIBIOTICS", JOURNAL OF LIPOSOME RESEARCH, TAYLOR & FRANCIS, PHILADELPHIA, PA, US, vol. 4, no. 1, 1 January 1994 (1994-01-01), pages 555 - 573, XP000564587, ISSN: 0898-2104
KIRBY C J ET AL: "STABILIZATION OF ASCORBIC ACID BY MICROENCAPSULATION IN LIPOSOMES", INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, BLACKWELL SCIENTIFIC PUBLICATIONS, OXFORD, GB, vol. 26, no. 5, 1 January 1991 (1991-01-01), pages 437 - 449, XP009045590, ISSN: 0950-5423
Attorney, Agent or Firm:
WITEK, Rafał (Witek Śnieżko & Partner, Weigla 12 Wrocław, PL)
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