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Title:
LIQUID ANTIBODY COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/217234
Kind Code:
A1
Abstract:
Disclosed in the present invention are a liquid antibody composition and the use thereof. The liquid antibody composition comprises a bispecific antibody targeting PD-L1 and CD47, an acidic buffer solution, a saccharide stabilizer and a polysorbate surfactant, and has a pH of 5.5-6.5, preferably 5.5-6.0. The composition has a good stability under the conditions of a high-concentration bispecific antibody.

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Inventors:
JI SHUANGYI (CN)
ZHANG YANZHEN (CN)
TANG PEIPEI (CN)
XIONG WENRUI (CN)
WANG AN (CN)
LI GANG (CN)
Application Number:
PCT/CN2023/093543
Publication Date:
November 16, 2023
Filing Date:
May 11, 2023
Export Citation:
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Assignee:
MABWELL SHANGHAI BIOSCIENCE CO LTD (CN)
International Classes:
A61K39/395; A61P35/00; C07K16/28; C12N15/13; C12N15/63
Foreign References:
CN114040777A2022-02-11
CN113121686A2021-07-16
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