Title:
LITHIUM DERIVATIVES OF PYRROLOQUINOLINE QUINONE AND PREPARATION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/111934
Kind Code:
A1
Abstract:
Lithium derivatives of pyrroloquinoline quinone and preparation method thereof are disclosed. In said method, lithium derivatives of pyrroloquinoline quinone are obtained by an acid-base neutralization reaction in a basic solvent with pyrroloquinoline quinine (PQQ) as a starting material. Lithium ion is brought in the molecular structure of pyrroloquinoline quinone to form said lithium derivatives of pyrroloquinoline quinone. The reaction condition of said method is mild, the product is easy to be purified, the preparation procedure is simple, and the yield is more than 80 %. Said lithium derivatives of pyrroloquinoline quinone possess GSK-3 inhibiting activity and possess the functions such as reducing the formation of age pigment in the brain of a transgenic mouse and reducing the phosphorylation of tau proteins. Said lithium derivatives of pyrroloquinoline quinone may be used in the manufacture of medicaments for preventing and treating senile dementia, senility or Parkinson's disease.
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Inventors:
ZHONG CHUNJIU (CN)
YANG QING (CN)
YANG QING (CN)
Application Number:
PCT/CN2010/071382
Publication Date:
October 07, 2010
Filing Date:
March 29, 2010
Export Citation:
Assignee:
SHANGHAI RIXIN BIO TECHONOLOGY (CN)
ZHONG CHUNJIU (CN)
YANG QING (CN)
ZHONG CHUNJIU (CN)
YANG QING (CN)
International Classes:
A61K31/435; C07D471/04; A61P25/00; A61P25/16; A61P25/28
Foreign References:
| CN101193888A | 2008-06-04 | |||
| JPH01305016A | 1989-12-08 |
Other References:
NATURE, vol. 422, 2003, pages 832
See also references of EP 2415770A4
See also references of EP 2415770A4
Attorney, Agent or Firm:
SHANGHAI EAST ASIA PATENT & TRADEMARK AGENCY CO., LTD. (MeiA/4F, Lane 672,No.33 Changle Rd., Jingan District, Shanghai 1, CN)
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