Title:
LIVER TARGETING DOMAIN ANTIBODIES
Document Type and Number:
WIPO Patent Application WO/2011/086143
Kind Code:
A3
Abstract:
The present invention relates to molecules that can be targeted to the liver. These liver targeting molecules (e.g.fusions and conjugates) comprise proteins, antibodies or antibody fragments such as immunoglobulin (antibody) single variable domains (dAbs) and also one or more additional molecules which it is desired to deliver to the liver such as interferons. The invention further relates to uses, formulations, compositions and devices comprising such liver targeting molecules. The invention also relates to immunoglobulin (antibody) single variable domains which bind to hepatocytes.
Inventors:
DUNLEVY GRAINNE (GB)
HOLMES STEVEN (GB)
HONG ZHI (US)
SEPP ARMIN (GB)
WALKER ADAM (GB)
HOLMES STEVEN (GB)
HONG ZHI (US)
SEPP ARMIN (GB)
WALKER ADAM (GB)
Application Number:
PCT/EP2011/050420
Publication Date:
December 01, 2011
Filing Date:
January 13, 2011
Export Citation:
Assignee:
GLAXO GROUP LTD (GB)
DUNLEVY GRAINNE (GB)
HOLMES STEVEN (GB)
HONG ZHI (US)
SEPP ARMIN (GB)
WALKER ADAM (GB)
DUNLEVY GRAINNE (GB)
HOLMES STEVEN (GB)
HONG ZHI (US)
SEPP ARMIN (GB)
WALKER ADAM (GB)
International Classes:
A61K39/395; A61K47/48; A61P1/16; A61P31/14; A61P35/00; C07K16/28; C07K19/00; C12N5/10; C12N15/13; C12N15/63
Domestic Patent References:
| WO1995018636A2 | 1995-07-13 | |||
| WO1992022310A1 | 1992-12-23 |
Foreign References:
| EP0308208A1 | 1989-03-22 |
Other References:
YANG YAN ET AL: "Cloning, expression and polyclonal antibody preparation of the asialoglycoprotein receptor of Marmota himalayan.", JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY. MEDICAL SCIENCES = HUA ZHONG KE JI DA XUE XUE BAO. YI XUE YING DE WEN BAN = HUAZHONG KEJI DAXUE XUEBAO. YIXUE YINGDEWEN BAN AUG 2007 LNKD- PUBMED:17828498, vol. 27, no. 4, August 2007 (2007-08-01), pages 411 - 414, XP002630202, ISSN: 1672-0733
CAO L ET AL: "Characterization of a single-chain variable fragment (scFv) antibody directed against the human asialoglycoprotein receptor", May 2006, BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY MAY 2006 PORTLAND PRESS LTD GB, VOL. 44, NR. 2, PAGE(S) 65 - 72, XP002643344
CAO L ET AL: "Characterization of a single-chain variable fragment (scFv) antibody directed against the human asialoglycoprotein receptor", May 2006, BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY MAY 2006 PORTLAND PRESS LTD GB, VOL. 44, NR. 2, PAGE(S) 65 - 72, XP002643344
Attorney, Agent or Firm:
KUCERNAK (NEE WILSON), Lynn et al. (Global Patents CN925.1980 Great West Road, Brentford Middlesex TW8 9GS, GB)
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