Title:
LIVER TARGETING DRUG, PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/088762
Kind Code:
A1
Abstract:
Disclosed are a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition and use thereof. The compound has significant liver targeting characteristics, can improve the efficacy while reducing the drug concentration in a circulating system, thereby reducing the toxic and side effects.
Inventors:
DU JESSICA XINYU (US)
Application Number:
PCT/CN2020/125832
Publication Date:
May 14, 2021
Filing Date:
November 02, 2020
Export Citation:
Assignee:
DU JESSICA XINYU (US)
HUANG QIANG (CN)
HUANG QIANG (CN)
International Classes:
C07D403/14; A61K31/404; A61P35/00
Domestic Patent References:
| WO2013049350A1 | 2013-04-04 | |||
| WO2013049350A1 | 2013-04-04 |
Foreign References:
| CN102471275A | 2012-05-23 | |||
| CN102471275A | 2012-05-23 |
Other References:
DENG YIJUN, XIE QIUZHE, LAPORTE MATTHEW G., CHASNOFF ANNA T. A., MORTENSEN MARK A., PATRA DEBASIS, PUTRELO SETH A., ANTONOVICH ROB: "Process Development and Synthesis of Birinapant: Large Scale Preparation and Acid-Mediated Dimerization of the Key Indole Intermediate", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 20, no. 2, 19 February 2016 (2016-02-19), US, pages 242 - 252, XP055810269, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.5b00390
DENG YIJUN, XIE QIUZHE, LAPORTE MATTHEW G., CHASNOFF ANNA T. A., MORTENSEN MARK A., PATRA DEBASIS, PUTRELO SETH A., ANTONOVICH ROB: "Process Development and Synthesis of Birinapant: Large Scale Preparation and Acid-Mediated Dimerization of the Key Indole Intermediate", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 20, no. 2, 19 February 2016 (2016-02-19), US, pages 242 - 252, XP055810269, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.5b00390
FANNING ET AL.: "Therapeutic strategies for hepatitis B virus infection: towards a cure", NATURE REVIEWS DRUG DISCOVERY, 2019
G. EBERT ET AL., PNAS, vol. 112, 2015, pages 5803
CHINESE JOURNAL OF APPLIED PHYSIOLOGY, 2018, pages 34524
MO ET AL., CELL CHEMICAL BIOLOGY, vol. 26, 2019, pages 1
See also references of EP 4056565A4
DENG YIJUN, XIE QIUZHE, LAPORTE MATTHEW G., CHASNOFF ANNA T. A., MORTENSEN MARK A., PATRA DEBASIS, PUTRELO SETH A., ANTONOVICH ROB: "Process Development and Synthesis of Birinapant: Large Scale Preparation and Acid-Mediated Dimerization of the Key Indole Intermediate", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 20, no. 2, 19 February 2016 (2016-02-19), US, pages 242 - 252, XP055810269, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.5b00390
FANNING ET AL.: "Therapeutic strategies for hepatitis B virus infection: towards a cure", NATURE REVIEWS DRUG DISCOVERY, 2019
G. EBERT ET AL., PNAS, vol. 112, 2015, pages 5803
CHINESE JOURNAL OF APPLIED PHYSIOLOGY, 2018, pages 34524
MO ET AL., CELL CHEMICAL BIOLOGY, vol. 26, 2019, pages 1
See also references of EP 4056565A4
Attorney, Agent or Firm:
BEIJING TANLULAI PATENT AGENT LTD (CN)
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