Title:
LOCAL TOPICAL FORMULATION CONTAINING JAK INHIBITOR OR SALT THEREOF OR CRYSTAL FORM THEREOF, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/020567
Kind Code:
A1
Abstract:
The present invention relates to the field of pharmaceutical formulations, and relates to a [1,2,4] triazolo [1,5-a] pyridine compound and an isomer thereof or a pharmaceutically acceptable salt thereof or a local topical formulation of a crystal form thereof, and an application thereof for skin disease; and specifically relates to a compound (S)-N-(5-(2-(2,2-difluorocyclopropanecarbonyl)-2-nitrogen spiro [3.5] non-7-yl)-[1, 2, 4] triazole [1,5-a] pyridin-2-yl) cyclopropanecarboxamide, and to an isomer thereof or a pharmaceutically acceptable salt thereof or a local topical formulation of a crystal form thereof, and an application thereof for skin disease; the skin disease is preferably psoriasis, atopic dermatitis, vitiligo, lupus erythematosus, alopecia areata, eczema, contact dermatitis, urticaria, dyshidrosis, dermatomyositis, scleroderma, acne and seborrheic dermatitis.
Inventors:
SHEN MEIYUE (CN)
MU LIWEI (CN)
YU TINGTING (CN)
HE YUJUN (CN)
SU CHONG (CN)
GAO PENG (CN)
WANG ZHENG (CN)
WANG DEGANG (CN)
MU LIWEI (CN)
YU TINGTING (CN)
HE YUJUN (CN)
SU CHONG (CN)
GAO PENG (CN)
WANG ZHENG (CN)
WANG DEGANG (CN)
Application Number:
PCT/CN2022/113223
Publication Date:
February 23, 2023
Filing Date:
August 18, 2022
Export Citation:
Assignee:
ZHUHAI UNITED LABORATORIES CO LTD (CN)
International Classes:
A61K9/06; A61K31/519; A61P17/00; A61P17/06; A61P17/14; C07D471/04; C07D487/00
Domestic Patent References:
| WO2020038457A1 | 2020-02-27 | |||
| WO2021046350A1 | 2021-03-11 | |||
| WO2020252012A1 | 2020-12-17 | |||
| WO2020038457A1 | 2020-02-27 |
Foreign References:
| CN112168774A | 2021-01-05 | |||
| CN112402615A | 2021-02-26 | |||
| CN103002875A | 2013-03-27 |
Attorney, Agent or Firm:
BEIJING LONGAN LAW FIRM (CN)
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