LONG-ACTING ACYLATED INSULIN DERIVATIVE AND USE THEREOF - BEIJING HUIZHIHENG BIOTECHNOLOGY CO LTD

Title:

LONG-ACTING ACYLATED INSULIN DERIVATIVE AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2024/051787

Kind Code:

A1

Abstract:

Provided are a long-acting acylated insulin derivative and use thereof and a preparation method therefor. The long-acting acylated insulin derivative is formed by connecting a fatty acid side chain to an insulin peptide chain in an acylation manner. The fatty acid side chain is connected to an epsilon amino of an amino acid K on the insulin peptide chain in an acylation manner. The peptide chain of the insulin derivative is composed of a modified insulin A chain and a modified insulin B chain. The long-acting acylated insulin derivative has remarkably prolonged action time, can be used for treating diabetes mellitus, can remarkably improve the compliance and sugar control willingness of a patient, and has wide market prospects.

Inventors:

CAO HAIYAN (CN)
LIN ZHAOSHENG (CN)
ZHU ZHIWEI (CN)
ZHANG HAIBO (CN)

Application Number:

PCT/CN2023/117567

Publication Date:

March 14, 2024

Filing Date:

September 07, 2023

Export Citation:

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Assignee:

BEIJING HUIZHIHENG BIOTECHNOLOGY CO LTD (CN)
HUISHENG BIOPHARMACEUTICAL CO LTD (CN)

International Classes:

C07K14/62; A61K38/00; A61K38/28; A61P5/50

Domestic Patent References:

WO2019193204A1	2019-10-10
WO2022078524A2	2022-04-21

Foreign References:

CN115947822A	2023-04-11
CN113395982A	2021-09-14
CN107743494A	2018-02-27
CN102037008A	2011-04-27
CN110691608A	2020-01-14
CN1133598A	1996-10-16
CN114891090A	2022-08-12

Other References:

HUBÁLEK FRANTISEK, REFSGAARD HANNE H. F., GRAM-NIELSEN SANNE, MADSEN PETER, NISHIMURA ERICA, MÜNZEL MARTIN, BRAND CHRISTIAN LEHN, : "Molecular engineering of safe and efficacious oral basal insulin", NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, UK, vol. 11, no. 1, UK, XP093146943, ISSN: 2041-1723, DOI: 10.1038/s41467-020-17487-9

Attorney, Agent or Firm:

BEIJING MIZAR STAR INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)

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