Title:
LONG-ACTING NERVE GROWTH FACTOR POLYPEPTIDES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/105847
Kind Code:
A1
Abstract:
Provided are long-acting nerve growth factor (NGF) polypeptides comprising from N-terminus to C-terminus an NGF moiety and an Fc moiety, methods of making, and uses thereof.
Inventors:
LI PING (CN)
ZHANG LEI (CN)
ZHANG LEI (CN)
Application Number:
PCT/CN2021/131614
Publication Date:
May 27, 2022
Filing Date:
November 19, 2021
Export Citation:
Assignee:
STAIDSON BEIJING BIOPHARMACEUTICALS CO LTD (CN)
International Classes:
C07K14/48; A61K38/18; A61P25/00; A61P25/28; C07K19/00; C12N15/62; C12N15/85
Domestic Patent References:
| WO2017157325A1 | 2017-09-21 | |||
| WO2019229701A2 | 2019-12-05 | |||
| WO2017157326A1 | 2017-09-21 | |||
| WO1999051642A1 | 1999-10-14 | |||
| WO2017157325A1 | 2017-09-21 | |||
| WO2017157326A1 | 2017-09-21 |
Foreign References:
| CN106008722A | 2016-10-12 | |||
| CN105273087A | 2016-01-27 | |||
| CN108300736A | 2018-07-20 | |||
| CN108727486A | 2018-11-02 | |||
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| US5821337A | 1998-10-13 | |||
| US6194551B1 | 2001-02-27 | |||
| CN107286233A | 2017-10-24 | |||
| CN103376248A | 2013-10-30 | |||
| CN108727486A | 2018-11-02 |
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KINET, ANNU. REV. IMMUNOL., vol. 9, 1991, pages 457 - 92
CLYNES ET AL., PNAS USA, vol. 95, 1998, pages 652 - 656
GAZZANO-SANTORO ET AL., J. IMMUNOL. METHODS, vol. 202, 1996, pages 163
IDUSOGIE ET AL., J. IMMUNOL., vol. 164, 2000, pages 4178 - 4184
HEZAREH ET AL., J VIROL, vol. 75, 2001, pages 12161 - 12168
OGANESYAN ET AL., ACTA CRYSTALLOGRAPHICA, vol. 64, 2008, pages 700 - 704
WANG ET AL.: "IgG Fc engineering to modulate antibody effector functions", PROTEIN CELL, vol. 9, no. 1, January 2018 (2018-01-01), pages 63 - 73, XP055457296, DOI: 10.1007/s13238-017-0473-8
YIN H ET AL., NATURE REV. GENETICS, vol. 15, 2014, pages 521 - 555
ARONOVICH EL ET AL.: "The Sleeping Beauty transposon system: a non-viral vector for gene therapy", HUM. MOL. GENET., vol. Rl, 2011, pages R14 - 20, XP055177523, DOI: 10.1093/hmg/ddr140
ZHAO S ET AL.: "PiggyBac transposon vectors: the tools of the human gene editing", TRANSL. LUNG CANCER RES., vol. 5, no. 1, 2016, pages 120 - 125, XP055923508, DOI: 10.3978/j.issn.2218-6751.2016.01.05
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