Title:
LONG-ACTING PALMITIC ACID-CONJUGATED GnRH DERIVATIVE, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2019/066199
Kind Code:
A1
Abstract:
The present invention relates to a novel long-acting palmitic acid-conjugated gonadotropin-releasing hormone (GnRH) derivative and a pharmaceutical composition containing the same. A GnRH derivative of the present invention is expected to greatly contribute, through excellent bioavailability and increased half-life in blood, to a reduction in drug dosing frequency and dosage and the like in the treatment of sex hormone-dependent diseases. Particularly, the GnRH derivative can overcome disadvantages of existing GnRH sustained-release preparations, which have side effects of a residual feeling and pain at the injection site.
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Inventors:
JIN DONG KYU (KR)
Application Number:
PCT/KR2018/006954
Publication Date:
April 04, 2019
Filing Date:
June 20, 2018
Export Citation:
Assignee:
JP BIO G INC (KR)
International Classes:
A61K47/54; A61K38/09; A61K47/65
Domestic Patent References:
| WO2015014653A1 | 2015-02-05 |
Foreign References:
| KR20140086722A | 2014-07-08 | |||
| KR20140027232A | 2014-03-06 | |||
| JPH1045625A | 1998-02-17 | |||
| KR20050084829A | 2005-08-29 | |||
| US20130060004A1 | 2013-03-07 | |||
| US9150615B2 | 2015-10-06 | |||
| US9694051B2 | 2017-07-04 |
Other References:
KUMAR P.SHARMA A, J HUM REPROD SCI, vol. 7, no. 3, 2014, pages 170 - 174
LEE PA ET AL., J. CLIN, ENDOCRINOL METAB, 2014
CHASIN M ET AL.: "Biodegradable Polymers as Drug Delivery Systems", 1990, MARCEL DEKKER
D. WESCMAN ET AL.: "Handbook of Biodegradable Polymers", 1998, TAYLOR & FRANCIS
See also references of EP 3639856A4
LEE PA ET AL., J. CLIN, ENDOCRINOL METAB, 2014
CHASIN M ET AL.: "Biodegradable Polymers as Drug Delivery Systems", 1990, MARCEL DEKKER
D. WESCMAN ET AL.: "Handbook of Biodegradable Polymers", 1998, TAYLOR & FRANCIS
See also references of EP 3639856A4
Attorney, Agent or Firm:
CHANG, Duck Soon et al. (KR)
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