Title:
LONG-ACTING SUPERHYDROPHOBIC ANTICOAGULATION BIOVALVE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/135454
Kind Code:
A1
Abstract:
A long-acting superhydrophobic anticoagulation biovalve and a preparation method therefor. The preparation method comprises the following steps: (1) treating a biovalve material with glutaraldehyde; (2) placing the biovalve material treated in step (1) into acid liquid containing a polyphenolic compound and metal ions, and adding an oxidant for reaction; and (3) reacting the biovalve material treated in step (2) with a hydrophobic substance. According to the method, a superhydrophobic coating having a long-acting high water contact angle and a low roll angle is prepared on the surface of the biovalve by means of a simple and stable operation process without affecting the performance of a valve body, and the requirements of long-acting anticoagulation are met by resisting the adsorption of plasma proteins.
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Inventors:
YANG LI (CN)
WANG YUNBING (CN)
LUO RIFANG (CN)
WANG YUNBING (CN)
LUO RIFANG (CN)
Application Number:
PCT/CN2021/140378
Publication Date:
June 30, 2022
Filing Date:
December 22, 2021
Export Citation:
Assignee:
JILIN VENUS HAOYUE MEDICAL LTD (CN)
International Classes:
A61L27/28; A61L27/34; A61L27/36; A61L27/50; C08G65/44
Foreign References:
| CN112641998A | 2021-04-13 | |||
| CN111420120A | 2020-07-17 | |||
| CN110152066A | 2019-08-23 | |||
| CN111569154A | 2020-08-25 | |||
| CN102114270A | 2011-07-06 | |||
| US5368608A | 1994-11-29 |
Attorney, Agent or Firm:
SHINY INTELLECTUAL PROPERTY FIRM (CN)
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