Title:
LONG-CHAIN ALKYL ESTER AMINE LIPID COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF IN NUCLEIC ACID DELIVERY
Document Type and Number:
WIPO Patent Application WO/2023/222081
Kind Code:
A1
Abstract:
Provided are a long-chain alkyl ester amine lipid compound represented by formula I, a preparation method therefor, and a use thereof in nucleic acid delivery. The long-chain alkyl ester amine lipid compound, as a lipid molecule, has excellent encapsulation efficiency and delivery effect in the delivery of disease treatment or a prophylactic agent, and also exhibits low toxicity and certain tissue distribution characteristics, providing more selective bases for the delivery of disease treatment or a prophylactic agent.
Inventors:
XING RUI (CN)
LV KAI (CN)
CEN SHAN (CN)
DONG YIJIE (CN)
LV KAI (CN)
CEN SHAN (CN)
DONG YIJIE (CN)
Application Number:
PCT/CN2023/095040
Publication Date:
November 23, 2023
Filing Date:
May 18, 2023
Export Citation:
Assignee:
RINUAGENE BIOTECHNOLOGY CO LTD (CN)
RINUAGENE INTERNATIONAL HK LTD (CN)
RINUAGENE INTERNATIONAL HK LTD (CN)
International Classes:
C07C229/16; A61K9/127; A61K31/7088; A61K31/713; A61K47/18; A61K48/00; A61P35/00; C07C227/08; C07C227/18; C07C227/40; C07C229/12
Domestic Patent References:
| WO2020061367A1 | 2020-03-26 | |||
| WO2018170260A1 | 2018-09-20 | |||
| WO2017201349A1 | 2017-11-23 |
Foreign References:
| CN115521220A | 2022-12-27 | |||
| CN115073316A | 2022-09-20 | |||
| CN110520409A | 2019-11-29 | |||
| CN109640962A | 2019-04-16 | |||
| CN113018449A | 2021-06-25 | |||
| CN113039174A | 2021-06-25 |
Attorney, Agent or Firm:
HAIWEN & PARTNERS (CN)
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