Title:
LONG NON-CODING RNA AND APPLICATION THEREOF IN DIAGNOSING/TREATING PREECLAMPSIA
Document Type and Number:
WIPO Patent Application WO/2018/094955
Kind Code:
A1
Abstract:
Provided is a long non-coding RNA, PVT1, and the nucleotide sequence thereof is shown in SEQ ID NO: 1. Also provided are a pharmaceutical composition comprising PVT1, a primer for detecting PVT1 and a kit comprising the primer, an siRNA for interfering PVT1, and an application of PVT1, the primer, or the pharmaceutical composition in preparing an agent/drug for diagnosing/treating preeclampsia.
Inventors:
SUN LIZHOU (CN)
XU YETAO (CN)
ZUO QING (CN)
HUANG SHIYUN (CN)
WU DAN (CN)
XU YETAO (CN)
ZUO QING (CN)
HUANG SHIYUN (CN)
WU DAN (CN)
Application Number:
PCT/CN2017/080715
Publication Date:
May 31, 2018
Filing Date:
April 17, 2017
Export Citation:
Assignee:
JIANGSU PROVINCE HOSPITAL (CN)
International Classes:
C12N15/113; A61K31/7105; A61K48/00; A61P9/12; A61P15/00; C12N15/11; C12Q1/68
Foreign References:
| CN105648075A | 2016-06-08 |
Other References:
" "Homo sapiens Pvt1 oncogene (non-protein coding) (PVT1), long non-coding RNA"", GENBANK NCBI REFERENCE SEQUENCE: NR_003367.3, 17 July 2013 (2013-07-17)
TAKAHASHI, Y. ET AL.: "Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers", BRITISH JOURNAL OF CANCER, vol. 110, no. 1, 5 November 2013 (2013-11-05), pages 164 - 171, XP055629631, ISSN: 0007-0920, DOI: 10.1038/bjc.2013.698
ZHENG, CHENGWU ET AL.: "Overexpression of the long non-coding RNA PVT1 is correlated with leukemic cell proliferation in acute promyelocytic leukemia", J HEMATOL ONCOL., vol. 8, no. 126, 6 November 2015 (2015-11-06), pages 1 - 6, XP055629639, DOI: 10.1186/s13045-015-0223-4
ZHANG, X.W. ET AL.: "Overexpression of long non-coding RNA PVT1 in gastric cancer cells promotes the development of multidrug resistance.", BIOCHEM BIOPHYS RES COMMUN., vol. 462, no. 3, 3 July 2015 (2015-07-03), pages 227 - 232, XP029141467, DOI: 10.1016/j.bbrc.2015.04.121
WAN, LI ET AL.: "Progession of long non-coding RNA PVT1 in tumor", CHINESE CLINICAL ONCOLOGY, vol. 21, no. 6, 30 June 2016 (2016-06-30), pages 569 - 572, ISSN: 1009-0460
ZHI, XIAOSONG ET AL.: "Progerssion of the role of long non-coding RNA PVT1 in tumor (non-official translation)", JOURNAL OF XINXIANG MEDICAL UNIVERSITY , vol. 33, no. 3, 31 March 2016 (2016-03-31), pages 243 - 245, ISSN: 1004-7239
TAKAHASHI, Y. ET AL.: "Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers", BRITISH JOURNAL OF CANCER, vol. 110, no. 1, 5 November 2013 (2013-11-05), pages 164 - 171, XP055629631, ISSN: 0007-0920, DOI: 10.1038/bjc.2013.698
ZHENG, CHENGWU ET AL.: "Overexpression of the long non-coding RNA PVT1 is correlated with leukemic cell proliferation in acute promyelocytic leukemia", J HEMATOL ONCOL., vol. 8, no. 126, 6 November 2015 (2015-11-06), pages 1 - 6, XP055629639, DOI: 10.1186/s13045-015-0223-4
ZHANG, X.W. ET AL.: "Overexpression of long non-coding RNA PVT1 in gastric cancer cells promotes the development of multidrug resistance.", BIOCHEM BIOPHYS RES COMMUN., vol. 462, no. 3, 3 July 2015 (2015-07-03), pages 227 - 232, XP029141467, DOI: 10.1016/j.bbrc.2015.04.121
WAN, LI ET AL.: "Progession of long non-coding RNA PVT1 in tumor", CHINESE CLINICAL ONCOLOGY, vol. 21, no. 6, 30 June 2016 (2016-06-30), pages 569 - 572, ISSN: 1009-0460
ZHI, XIAOSONG ET AL.: "Progerssion of the role of long non-coding RNA PVT1 in tumor (non-official translation)", JOURNAL OF XINXIANG MEDICAL UNIVERSITY , vol. 33, no. 3, 31 March 2016 (2016-03-31), pages 243 - 245, ISSN: 1004-7239
Attorney, Agent or Firm:
BEIJING CHENGHUI LAW FIRM (CN)
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