Title:
LOTION
Document Type and Number:
WIPO Patent Application WO/1994/028894
Kind Code:
A1
Abstract:
A lotion comprising a tricyclic compound represented by 17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone or a pharmaceutically acceptable salt thereof, a dissolution/absorption promoter, a liquid medium, and optionally an emulsifying agent or a mixture thereof with a thickening agent. The lotion is stable and excellent in absorbability, scarcely irritates the skin, and can be sustainedly released. It is useful for treating and preventing inflammatory and proliferative dermatoses and immunologically mediated skin diseases.
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Inventors:
KAGAYAMA AKIRA (JP)
TANIMOTO SACHIYO (JP)
MURATA SABURO (JP)
HATA TAKEHISA (JP)
TANIMOTO SACHIYO (JP)
MURATA SABURO (JP)
HATA TAKEHISA (JP)
Application Number:
PCT/JP1994/000863
Publication Date:
December 22, 1994
Filing Date:
May 30, 1994
Export Citation:
Assignee:
FUJISAWA PHARMACEUTICAL CO (JP)
KAGAYAMA AKIRA (JP)
TANIMOTO SACHIYO (JP)
MURATA SABURO (JP)
HATA TAKEHISA (JP)
KAGAYAMA AKIRA (JP)
TANIMOTO SACHIYO (JP)
MURATA SABURO (JP)
HATA TAKEHISA (JP)
International Classes:
A61K9/00; A61K31/40; A61K31/407; A61K31/435; A61K31/436; A61K31/55; A61K9/107; A61K47/00; A61K47/10; A61K47/14; A61K47/18; A61K47/24; A61P17/00; A61P29/00; C07D498/18; A61K47/32; A61K47/44; (IPC1-7): A61K31/40; A61K31/445; A61K31/55; A61K9/08; A61K47/14; A61K47/32
Foreign References:
| JPS61148181A | 1986-07-05 | |||
| JPH01157913A | 1989-06-21 | |||
| JPS60228412A | 1985-11-13 | |||
| JPH03258717A | 1991-11-19 | |||
| JPH03173816A | 1991-07-29 | |||
| JPH0283314A | 1990-03-23 | |||
| JPH01143831A | 1989-06-06 | |||
| JPS6322507A | 1988-01-30 |
Other References:
See also references of EP 0753297A4
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