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Title:
LOW-MOLECULAR POLYSULFATED HYALURONIC ACID DERIVATIVE AND MEDICINE CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2010/087207
Kind Code:
A1
Abstract:
A low-molecular polysulfated hyaluronic acid derivative useful in the prevention and/or treatment of allergic diseases. Provided is a preventive and/or therapeutic agent for an allergic disease selected from pollinosis, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, and asthma, the agent containing either a low-molecular polysulfated hyaluronic acid derivative represented by general formula (IA) or (IB) or a pharmaceutically acceptable salt thereof as an active ingredient. [In the formulae, n is a number of 0-15, and Rs each independently represents a hydrogen atom, an SO3H group, etc.]

Inventors:
KAKEHI KAZUAKI (JP)
ASAI HIROAKI (JP)
HAYASHI NAOHIRO (JP)
SHIMIZU SATOSHI (JP)
GOTO FUMITAKA (JP)
KOGA YASUO (JP)
TOMOYASU TAKAHIRO (JP)
TAKI TAKAO (JP)
KATO YUSUKE (JP)
NAKAZATO SATORU (JP)
TAKABA JUNJI (JP)
AZUMA ATSUSHI (JP)
HIRANO WAKAKO (JP)
IZUMI KAZUNARI (JP)
KASHIMOTO MINORU (JP)
SAKAMOTO YOKO (JP)
HAYASHI TAKASHI (JP)
NISHIDA MASARU (JP)
Application Number:
PCT/JP2010/000583
Publication Date:
August 05, 2010
Filing Date:
February 01, 2010
Export Citation:
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Assignee:
OTSUKA CHEMICAL CO LTD (JP)
OTSUKA PHARMA CO LTD (JP)
KAKEHI KAZUAKI (JP)
ASAI HIROAKI (JP)
HAYASHI NAOHIRO (JP)
SHIMIZU SATOSHI (JP)
GOTO FUMITAKA (JP)
KOGA YASUO (JP)
TOMOYASU TAKAHIRO (JP)
TAKI TAKAO (JP)
KATO YUSUKE (JP)
NAKAZATO SATORU (JP)
TAKABA JUNJI (JP)
AZUMA ATSUSHI (JP)
HIRANO WAKAKO (JP)
IZUMI KAZUNARI (JP)
KASHIMOTO MINORU (JP)
SAKAMOTO YOKO (JP)
HAYASHI TAKASHI (JP)
NISHIDA MASARU (JP)
International Classes:
A61K31/728; C07H15/04; A61P11/02; A61P11/06; A61P17/00; A61P27/14; A61P37/08; C08B37/08
Domestic Patent References:
WO2004011662A12004-02-05
Foreign References:
JP2006517185A2006-07-20
JPH11335288A1999-12-07
JPH11269077A1999-10-05
JPH08277224A1996-10-22
JPH11147901A1999-06-02
JPH11269077A1999-10-05
JPH11335288A1999-12-07
JPH08277224A1996-10-22
JPH10195107A1998-07-28
Other References:
SUZUKI, A. ET AL.: "Preparation and inhibitory activity on hyaluronidase of fully 0-sulfated hyaluro-oligosaccharides", GLYCOBIOLOGY, vol. 11, no. 1, 2001, pages 57 - 64, XP002648213
TAKAGAKI, K. ET AL.: "Domain structure of chondroitin sulfate E octasaccharides binding to type V collagen", J. BIOL. CHEM., vol. 277, no. 11, 2002, pages 8882 - 8889, XP002371341
JOBE, K.L. ET AL.: "Interleukin-12 release from macrophages by hyaluronan, chondroitin sulfate A and chondroitin sulfate C oligosaccharides", IMMUNOL. LETT., vol. 89, 2003, pages 99 - 109, XP009061828
GLYCOBIOLOGY, vol. 11, no. 1, 2001, pages 57 - 64
REISSIG. J. L. ET AL., J. BIOL. CHEM., vol. 217, 1955, pages 959
GLYCOBIOLOGY, vol. 12, no. 7, 2002, pages 421 - 426
See also references of EP 2392579A4
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
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