LRRC-15-BINDING PROTEIN CONSTRUCTS AND USES THEREOF

Title:

LRRC-15-BINDING PROTEIN CONSTRUCTS AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2024/081729

Kind Code:

A3

Abstract:

Provided herein are antigen-binding protein constructs (ABPCs), antibodies, and antibody drug conjugates (ADCs) that bind LRRC15, and uses of the same.

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Inventors:

GERA NIMISH (US)
FISKE BRIAN (US)
FITZGERALD KYLE MICHAEL (US)

Application Number:

PCT/US2023/076593

Publication Date:

May 16, 2024

Filing Date:

October 11, 2023

Export Citation:

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Assignee:

MYTHIC THERAPEUTICS INC (US)

International Classes:

C07K16/28; A61K39/395; A61K47/68; A61P35/00; C07K16/30

Domestic Patent References:

WO2021202642A2	2021-10-07
WO2021022304A2	2021-02-04
WO2022157094A2	2022-07-28
WO2017095805A1	2017-06-08
WO2017095808A1	2017-06-08
WO2005094348A2	2005-10-13
WO2020247827A1	2020-12-10
WO2021050871A1	2021-03-18
WO2022216653A1	2022-10-13

Other References:

HINGORANI POOJA ET AL: "ABBV-085, Antibody-Drug Conjugate Targeting LRRC15, Is Effective in Osteosarcoma: A Report by the Pediatric Preclinical Testing Consortium", MOLECULAR CANCER THERAPEUTICS, vol. 20, no. 3, 1 March 2021 (2021-03-01), US, pages 535 - 540, XP055950975, ISSN: 1535-7163, Retrieved from the Internet DOI: 10.1158/1535-7163.MCT-20-0406
TRAIAN SULEA ET AL: "Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment", MABS, vol. 12, no. 1, 28 November 2019 (2019-11-28), US, pages 1 - 15, XP055748452, ISSN: 1942-0862, DOI: 10.1080/19420862.2019.1682866

Attorney, Agent or Firm:

PADILLA, Garett M. et al. (US)

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