LRRC15 ANTIBODIES AND CONJUGATES THEREOF

Title:

LRRC15 ANTIBODIES AND CONJUGATES THEREOF

Document Type and Number:

WIPO Patent Application WO/2022/157094

Kind Code:

A3

Abstract:

The present invention relates to conjugates comprising a chelator arranged for complexation of a radionuclide and a targeting moiety binding to LRRC15. For example, the conjugates according to the current invention can be targeted alpha therapeutics such as targeted thorium conjugates (TTCs), i.e. radioconjugates comprising an alpha emitter, such as 227Th. The present invention further relates to sequence-defined antibodies binding LRRC15 and antigen-binding fragments thereof. Also provided are conjugates comprising these antibodies or functional fragments thereof. The antibodies, functional fragments and conjugates according to the current invention can be used to treat cancer and other disorders and conditions associated with the expression of LRRC15. Provided are pharmaceutical compositions and kits with instructions for use comprising the antibodies, functional fragments and conjugates according to the current invention. The invention further provides methods and tools to generate the antibodies, functional fragments and conjugates according to the invention. For example, provided are polynucleotides encoding the foregoing antibodies or fragments, vectors containing the same, and cells for production.

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Inventors:

TRAUTWEIN MARK (DE)
HAGEMANN URS BEAT (DE)
ELLINGER PHILLIPP (DE)
MÄRSCH STEPHAN (DE)
SCHUHMACHER JOACHIM (DE)
WENGNER ANTJE MARGRET (DE)
BJERKE ROGER MALERBAKKEN (NO)
ROIDER HELGE (DE)

Application Number:

PCT/EP2022/050831

Publication Date:

September 15, 2022

Filing Date:

January 17, 2022

Export Citation:

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Assignee:

BAYER AG (DE)
BAYER AS (NO)

International Classes:

C07K16/28; A61K51/10; A61P35/00

Domestic Patent References:

WO2005037999A2	2005-04-28
WO2016096843A1	2016-06-23

Foreign References:

US20170151344A1

2017-06-01

Other References:

JAMES W. PURCELL ET AL, CANCER RESEARCH, vol. 78, no. 14, 15 July 2018 (2018-07-15), US, pages 4059 - 4072, XP055745280, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-18-0327

Attorney, Agent or Firm:

BIP PATENTS (DE)

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