Title:
LUNG ADENOCARCINOMA MOLECULAR TYPING AND SURVIVAL RISK FACTOR GENE CLUSTER, DIAGNOSTIC PRODUCT, AND APPLICATION
Document Type and Number:
WIPO Patent Application WO/2021/037134
Kind Code:
A1
Abstract:
Disclosed are a gene cluster which can evaluate lung adenocarcinoma molecular typing and survival risk, and an application of a reagent, which detects the gene expression level of the gene cluster, in preparing a product, the product being used for determining lung adenocarcinoma molecular typing and evaluating lung adenocarcinoma patient survival risk, the product comprising a next-generation sequencing (NGS) detection reagent kit, a fluorescence quantitative PCR detection reagent kit, a gene chip and a protein microarray. Also disclosed is a method which uses the detection reagent kits to evaluate lung adenocarcinoma molecular typing and survival risk.
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Inventors:
ZHOU TONG (CN)
ZHOU WEIQING (CN)
HU ZHIYUAN (CN)
MA LINLIN (CN)
LU JUNHUAN (CN)
ZHOU WEIQING (CN)
HU ZHIYUAN (CN)
MA LINLIN (CN)
LU JUNHUAN (CN)
Application Number:
PCT/CN2020/111702
Publication Date:
March 04, 2021
Filing Date:
August 27, 2020
Export Citation:
Assignee:
SHANGHAI PREC DIAGNOSTICS CO LTD (CN)
International Classes:
C12Q1/6886; C40B40/06; G01N33/574
Domestic Patent References:
| WO2019018764A1 | 2019-01-24 |
Foreign References:
| CN107849569A | 2018-03-27 | |||
| CN101111768A | 2008-01-23 | |||
| CN109790583A | 2019-05-21 |
Other References:
XU YAN , SHEN XIAO-XING , LIU BIAO , RAO QIN , SHI SHAN-SHAN , WANG XUAN , HE YAN , HUANG PEI-LIN: "The Abnormal Expression and the Clinicopathologic Significance of Polo-like Kinase 1(PLK1) in Adenocarcinoma of the Lung", JOURNAL OF SOUTHEAST UNIVERSITY (MEDICAL SCIENCE EDITION), vol. 36, no. 5, 31 October 2017 (2017-10-31), pages 804 - 810, XP055786898, ISSN: 1671-6264, DOI: 10.3969/j.issn.1671-6264.2017.05.025
LI LIFENG, PENG MENGLE, XUE WENHUA, FAN ZHIRUI, WANG TIAN, LIAN JINGYAO, ZHAI YUNKAI, LIAN WENPING, QIN DONGCHUN, ZHAO JIE: "Integrated analysis of dysregulated long non-coding RNAs/microRNAs/mRNAs in metastasis of lung adenocarcinoma", JOURNAL OF TRANSLATIONAL MEDICINE, vol. 16, no. 1, 372, 27 December 2018 (2018-12-27), pages 1 - 14, XP055786903, DOI: 10.1186/s12967-018-1732-z
PING ZHAN; XIAO-KUN SHEN; QIAN QIAN; JI-PING ZHU; YU ZHANG; HAI-YAN XIE; CHUEN-HUA XU; KE-KE HAO; WEI HU; NING XIA; GUO-JUN LU; LI: "Down-Regulation of Lysyl Oxidase-like 2 (LOXL2) Is Associated with Disease Progression in Lung Adenocarcinomas", MEDICAL ONCOLOGY, vol. 29, no. 2, 26 April 2011 (2011-04-26), pages 648 - 655, XP035049731, ISSN: 1559-131X, DOI: 10.1007/s12032-011-9959-z
HARTWIG TORSTEN; MONTINARO ANTONELLA; VON KARSTEDT SILVIA; SEVKO ALEXANDRA; SURINOVA SILVIA; CHAKRAVARTHY ANKUR; TARABORRELLI LUCI: "The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune", MOLECULAR CELL, vol. 65, no. 4, 16 February 2017 (2017-02-16), pages 730 - 742, XP029924363, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2017.01.021
SINGH MOHINI; VENUGOPAL CHITRA; TOKAR TOMAS; BROWN KEVIN R; MCFARLANE NICOLE; BAKHSHINYAN DAVID; VIJAYAKUMAR THUSYANTH; MANORANJAN: "RNAi Screen Identifies Essential Regulators of Human Brain Metastasis Initiating Cells", ACTA NEUROPATHOLOGICA, vol. 134, no. 6, 1 August 2017 (2017-08-01), pages 923 - 940, XP036351198, ISSN: 0001-6322, DOI: 10.1007/s00401-017-1757-z
LI LIFENG, PENG MENGLE, XUE WENHUA, FAN ZHIRUI, WANG TIAN, LIAN JINGYAO, ZHAI YUNKAI, LIAN WENPING, QIN DONGCHUN, ZHAO JIE: "Integrated analysis of dysregulated long non-coding RNAs/microRNAs/mRNAs in metastasis of lung adenocarcinoma", JOURNAL OF TRANSLATIONAL MEDICINE, vol. 16, no. 1, 372, 27 December 2018 (2018-12-27), pages 1 - 14, XP055786903, DOI: 10.1186/s12967-018-1732-z
PING ZHAN; XIAO-KUN SHEN; QIAN QIAN; JI-PING ZHU; YU ZHANG; HAI-YAN XIE; CHUEN-HUA XU; KE-KE HAO; WEI HU; NING XIA; GUO-JUN LU; LI: "Down-Regulation of Lysyl Oxidase-like 2 (LOXL2) Is Associated with Disease Progression in Lung Adenocarcinomas", MEDICAL ONCOLOGY, vol. 29, no. 2, 26 April 2011 (2011-04-26), pages 648 - 655, XP035049731, ISSN: 1559-131X, DOI: 10.1007/s12032-011-9959-z
HARTWIG TORSTEN; MONTINARO ANTONELLA; VON KARSTEDT SILVIA; SEVKO ALEXANDRA; SURINOVA SILVIA; CHAKRAVARTHY ANKUR; TARABORRELLI LUCI: "The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune", MOLECULAR CELL, vol. 65, no. 4, 16 February 2017 (2017-02-16), pages 730 - 742, XP029924363, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2017.01.021
SINGH MOHINI; VENUGOPAL CHITRA; TOKAR TOMAS; BROWN KEVIN R; MCFARLANE NICOLE; BAKHSHINYAN DAVID; VIJAYAKUMAR THUSYANTH; MANORANJAN: "RNAi Screen Identifies Essential Regulators of Human Brain Metastasis Initiating Cells", ACTA NEUROPATHOLOGICA, vol. 134, no. 6, 1 August 2017 (2017-08-01), pages 923 - 940, XP036351198, ISSN: 0001-6322, DOI: 10.1007/s00401-017-1757-z
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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