Title:
LUNG STEM CELLS AND LUNG REGENERATION
Document Type and Number:
WIPO Patent Application WO2001042425
Kind Code:
A3
Abstract:
A method of stimulating the growth of lung alveolar surface in a lung comprises providing progenitor or stem cells capable of regenerating lung alveolar surface, and then administering the progenitor or stem cells to the lung in an amount sufficient to stimulate the growth of lung alveolar surface therein.
Inventors:
SCHWARZ MARGARET (US)
WARBURTON DAVID (US)
DRISCOLL BARBARA (US)
BUCKLEY SUSAN A (US)
WARBURTON DAVID (US)
DRISCOLL BARBARA (US)
BUCKLEY SUSAN A (US)
Application Number:
PCT/US2000/042646
Publication Date:
May 10, 2002
Filing Date:
December 07, 2000
Export Citation:
Assignee:
LOS ANGELES CHILDRENS HOSPITAL (US)
SCHWARZ MARGARET (US)
WARBURTON DAVID (US)
DRISCOLL BARBARA (US)
BUCKLEY SUSAN A (US)
SCHWARZ MARGARET (US)
WARBURTON DAVID (US)
DRISCOLL BARBARA (US)
BUCKLEY SUSAN A (US)
International Classes:
A61K35/42; C12N5/071; C12N5/074; A61K35/12; (IPC1-7): A01N63/00; A61K48/00; A61K35/42; C12N5/08
Foreign References:
| US5859068A | 1999-01-12 |
Other References:
WARBURTON ET AL.: "Commitment and differentiation of lung cell lineages", BIOCHEM. CELL BIOL., vol. 76, 1998, pages 971 - 995, XP002942522
ZEPEDA ET AL.: "Characterization of stem cells in human airway capable of reconstituting a fully differentiated epithelium", SOMATIC CELL AND MOLECULAR GENETICS, vol. 21, no. 1, 1995, pages 61 - 73, XP002942523
OTTO ET AL.: "Lung stem cells", INT. J. EXP. PATHOL., vol. 78, no. 5, October 1997 (1997-10-01), pages 291 - 310, XP002942524
SHAABAN ET AL.: "Fetal hematopoietic stem cell transplantation", SEMINARS IN PERINATOLOGY, vol. 23, no. 6, December 1999 (1999-12-01), pages 515 - 523, XP002942525
CHAPELIER ET AL.: "Gene therapy in lung transplantation: feasibility of ex vivo adenovirus-mediated gene transfer to the graft", HUMAN GENE THERAPY, vol. 7, 1 October 1996 (1996-10-01), pages 1837 - 1845, XP002942526
ZEPEDA ET AL.: "Characterization of stem cells in human airway capable of reconstituting a fully differentiated epithelium", SOMATIC CELL AND MOLECULAR GENETICS, vol. 21, no. 1, 1995, pages 61 - 73, XP002942523
OTTO ET AL.: "Lung stem cells", INT. J. EXP. PATHOL., vol. 78, no. 5, October 1997 (1997-10-01), pages 291 - 310, XP002942524
SHAABAN ET AL.: "Fetal hematopoietic stem cell transplantation", SEMINARS IN PERINATOLOGY, vol. 23, no. 6, December 1999 (1999-12-01), pages 515 - 523, XP002942525
CHAPELIER ET AL.: "Gene therapy in lung transplantation: feasibility of ex vivo adenovirus-mediated gene transfer to the graft", HUMAN GENE THERAPY, vol. 7, 1 October 1996 (1996-10-01), pages 1837 - 1845, XP002942526
Download PDF: