Title:
LYMPHOCYTES-ANTIGEN PRESENTING CELLS CO-STIMULATORS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/036495
Kind Code:
A9
Abstract:
Disclosed herein are fusion proteins having a first domain that activates an antigen-presenting cell (APC) (e.g.a dendritic cell) by binding to an activation receptor of the APC, and a second domain that activates an immune effector cell (e.g.a T cell) by targeting a co-stimulatory signaling pathway of the immune effector cell, as well as polynucleotides that encode such fusion proteins. Disclosed herein are also genetically engineered immune effector cells expressing such fusion protein, methods of their production, and their uses in treatment of diseases such as cancers.
Inventors:
ZHAO YANGBING (CN)
LIU XIAOJUN (CN)
LIU XIAOJUN (CN)
Application Number:
PCT/CN2020/109484
Publication Date:
May 19, 2022
Filing Date:
August 17, 2020
Export Citation:
Assignee:
UTC THERAPEUTICS SHANGHAI CO LTD (CN)
International Classes:
A61K35/14; A61P35/00; C07K16/28
Attorney, Agent or Firm:
J.Z.M.C. PATENT AND TRADEMARK LAW OFFICE (GENERAL PARTNERSHIP) (CN)
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