LYMPHOCYTIC ACTIVATION INHIBITOR AND REMEDIAL AGENT FOR AUTOIMMUNE DISEASE

Title:

LYMPHOCYTIC ACTIVATION INHIBITOR AND REMEDIAL AGENT FOR AUTOIMMUNE DISEASE

Document Type and Number:

WIPO Patent Application WO/2003/022271

Kind Code:

A1

Abstract:

A lymphocytic activation inhibitor and a remedial agent for autoimmune diseases which each comprises as an active ingredient a sulfonamide derivative or sulfonic ester derivative represented by the general formula (I): (I) [wherein ring A means an optionally substituted, mono− or bicyclic aromatic ring&semi ring B means an optionally substituted, 6−membered, cyclic unsaturated hydrocarbon or an unsaturated 6−membered heterocycle containing one nitrogen atom&semi ring C means an optionally substituted 5−membered heterocycle containing one or two nitrogen atoms&semi W means a single bond or −CH=CH−&semi X means −N(R¹)− or oxygen&semi Y means carbon or nitrogen&semi Z means −N(R²)− or nitrogen&semi and R¹ and R² are the same or different and each means hydrogen or lower alkyl], a pharmacologically acceptable salt thereof, or a hydrate of any of these.

Inventors:

HANADA TAKAHISA (JP)
YAMAUCHI TOSHIHIKO (JP)
CHIBA KENICHI (JP)
OWA TAKASHI (JP)
HIDA TAKAYUKI (JP)
MIYAMOTO NORIMASA (JP)

Application Number:

PCT/JP2002/009030

Publication Date:

March 20, 2003

Filing Date:

September 05, 2002

Export Citation:

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Assignee:

EISAI C0 LTD (JP)
HANADA TAKAHISA (JP)
YAMAUCHI TOSHIHIKO (JP)
CHIBA KENICHI (JP)
OWA TAKASHI (JP)
HIDA TAKAYUKI (JP)
MIYAMOTO NORIMASA (JP)

International Classes:

A61K31/404; A61K31/416; A61K31/4178; A61K31/427; A61K31/437; A61K31/4439; A61K45/06; A61P1/00; A61P1/02; A61P3/10; A61P5/50; A61P19/02; A61P19/04; A61P25/00; A61P27/02; A61P29/00; A61P37/00; A61P37/02; (IPC1-7): A61K31/404; A61K31/416; A61K31/4178; A61K31/427; A61K31/437; A61K31/4439; A61K45/00; A61P1/00; A61P1/02; A61P3/10; A61P5/50; A61P19/02; A61P19/04; A61P25/00; A61P27/02; A61P29/00; A61P37/00; A61P37/02; C07D209/30; C07D209/34; C07D209/42; C07D231/56; C07D401/12; C07D403/12; C07D405/12; C07D409/14; C07D417/12; C07D471/04

Domestic Patent References:

WO2001056607A1	2001-08-09
WO2001053266A1	2001-07-26
WO2000050395A1	2000-08-31
WO1999018076A1	1999-04-15
WO1997048368A2	1997-12-24

Foreign References:

JP2002167376A	2002-06-11
JP2000309534A	2000-11-07
US5939431A	1999-08-17
JPS5589222A	1980-07-05

Other References: