Title:
LYOPHILIZED PREPARATION AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2018/028531
Kind Code:
A1
Abstract:
Provided are a lyophilized preparation and a preparation method therefor. The method comprises the following steps: a) mixing and freezing raw materials for preparation to obtain a soft ice mixture, the raw materials for preparation comprising an active ingredient, a binder and water; The mass ratio of the active ingredient to the binder is 0～100:0～100, and the content of the two cannot be 0 simultaneously; b) processing the soft ice mixture using a filling machine, and releasing the soft ice mixture to the environment for solidification forming, so as to obtain a cured product, the filling machine being selected from a pipetting device, a plunger pump, a screw pump, a gear pump or a peristaltic pump; c) freeze-drying the cured product to obtain a lyophilized preparation. The shape of the lyophilized preparation prepared by the preparation method is controllable and the drug loading is higher; The lyophilized preparation has good preparation strength, fast disintegration rate and good solubility. Test results indicate that: The drug loading of the lyophilized preparation is 0.01-99.9%, with preparation friability being less than 0.1%, preparation disintegration time in water being less than15s, and complete dissolution time being less than 15s.
Inventors:
DONG LING (CN)
Application Number:
PCT/CN2017/096167
Publication Date:
February 15, 2018
Filing Date:
August 07, 2017
Export Citation:
Assignee:
DONG LING (CN)
International Classes:
A61K9/19; A61K9/00; F26B5/06
Foreign References:
| CN103191069A | 2013-07-10 | |||
| CN106963737A | 2017-07-21 | |||
| CN106821770A | 2017-06-13 | |||
| CN106551804A | 2017-04-05 | |||
| US20070172528A1 | 2007-07-26 |
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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