Title:
METHOD FOR IMMUNOASSAYING SOLUBLE Fas ANTIGEN AND KIT THEREFOR
Document Type and Number:
WIPO Patent Application WO/1996/001277
Kind Code:
A1
Abstract:
A kit and a method for immunoassaying soluble Fas antigens present in a body fluid such as serum, whereby the quantity of soluble Fas antigens present in the body fluid of a patient with autoimmune diseases such as rheumatism or SLE, which has been difficult to determine heretofore, can be determined readily with high accuracy and sensitivity, and a large quantity of specimens can be assayed at once. The invention also provides a soluble Fas antigen as a soluble active substance which is very useful as a pure standard to be used in the above method and kit and as an immunizing antigen to be used for producing monoclonal antibodies against the soluble region of a Fas antigen.
Inventors:
YONEHARA SHIN (JP)
NOGUCHI JUN (JP)
HACHIYA TAKAHISA (JP)
NOGUCHI JUN (JP)
HACHIYA TAKAHISA (JP)
Application Number:
PCT/JP1995/000349
Publication Date:
January 18, 1996
Filing Date:
March 03, 1995
Export Citation:
Assignee:
MED & BIOLOGICAL LAB CO LTD (JP)
JAPAN TOBACCO INC (JP)
YONEHARA SHIN (JP)
NOGUCHI JUN (JP)
HACHIYA TAKAHISA (JP)
JAPAN TOBACCO INC (JP)
YONEHARA SHIN (JP)
NOGUCHI JUN (JP)
HACHIYA TAKAHISA (JP)
International Classes:
C07K14/715; G01N33/543; G01N33/564; G01N33/577; G01N33/53; (IPC1-7): C07K16/28; C12P21/02; C12P21/08; C12N5/10; C12N1/21; C12N15/13; C12N15/62; G01N33/577; G01N33/53
Other References:
PROC. NATL. ACAD. SCI. U.S.A., Vol. 91, (May 1994), SHINO HANABUCHI et al., "Fas and Its Ligand in a General Mechanism of T-Cell-Mediated Cytotoxicity", pages 4930-4934.
CELL, Vol. 75, (December 1993), TAKASHI SUDA et al., "Molecular Cloning and Expression of the Fas Ligand, a Novel Member of the Tumor Necrosis Factor Family", pages 1169-1178.
SCIENCE, Vol. 263, (March 1994), JIANHUA CHENG et al., "Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas Molecule", pages 1759-1762.
JOURNAL OF LEUKOCYTE BIOLOGY, (1993), BRENDAN CLASSON et al., "Expression of a Soluble Form of the Fas Antigen", Suppl. page 63.
JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 267, No. 2, (January 1992), HUEY-MEI WANG et al., "Structure of Mouse Interleukin 3 (IL-3) Binding Protein (AIC2A)", pages 979-983.
JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 267, No. 15, (May 1992), ALEXANDER OEHM et al., "Purification and Molecular Cloning of the APO-1 Cell Surface Antigen, A Member of the Tumor Necrosis Factor/Nerve Growth Factor Receptor Superfamily", pages 10709-10715.
CELL, Vol. 75, (December 1993), TAKASHI SUDA et al., "Molecular Cloning and Expression of the Fas Ligand, a Novel Member of the Tumor Necrosis Factor Family", pages 1169-1178.
SCIENCE, Vol. 263, (March 1994), JIANHUA CHENG et al., "Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas Molecule", pages 1759-1762.
JOURNAL OF LEUKOCYTE BIOLOGY, (1993), BRENDAN CLASSON et al., "Expression of a Soluble Form of the Fas Antigen", Suppl. page 63.
JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 267, No. 2, (January 1992), HUEY-MEI WANG et al., "Structure of Mouse Interleukin 3 (IL-3) Binding Protein (AIC2A)", pages 979-983.
JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 267, No. 15, (May 1992), ALEXANDER OEHM et al., "Purification and Molecular Cloning of the APO-1 Cell Surface Antigen, A Member of the Tumor Necrosis Factor/Nerve Growth Factor Receptor Superfamily", pages 10709-10715.
Download PDF:
Previous Patent: EXPRESSION OF A FUNCTIONAL HUMAN TYPE I INTERFERON RECEPTOR
Next Patent: CATALYST SYSTEM FOR THE POLYMERIZATION OF ETHYLENE
Next Patent: CATALYST SYSTEM FOR THE POLYMERIZATION OF ETHYLENE