Title:
METHOD OF MEASURING INSULIN RECEPTOR &agr SUBUNIT
Document Type and Number:
WIPO Patent Application WO/2004/097414
Kind Code:
A1
Abstract:
It has been found that free insulin receptor &agr subunits are present in the blood. There is provided a method of measuring insulin receptor &agr subunits, comprising the step of bringing insulin receptor &agr subunits of a blood sample into contact with an antibody capable of recognizing insulin receptor &agr subunits and detecting bonding therebetween. The measuring of free insulin receptor &agr subunits in the blood is useful for estimation of a risk factor of diabetes. Further, it has been clarified by the measuring method that the concentration of free insulin receptor &agr subunits in the blood of patients with diabetes or cancer is significantly high. The free insulin receptor &agr subunits in the blood are useful as a marker for diabetes or cancer.
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Inventors:
EBINA YOUSUKE (JP)
OBATA TOSHIYUKI (JP)
OKAMOTO EIJI (JP)
OBATA TOSHIYUKI (JP)
OKAMOTO EIJI (JP)
Application Number:
PCT/JP2004/005412
Publication Date:
November 11, 2004
Filing Date:
April 15, 2004
Export Citation:
Assignee:
EBINA YOUSUKE (JP)
OBATA TOSHIYUKI (JP)
MEDICAL & BIOL LAB CO LTD (JP)
OKAMOTO EIJI (JP)
OBATA TOSHIYUKI (JP)
MEDICAL & BIOL LAB CO LTD (JP)
OKAMOTO EIJI (JP)
International Classes:
C07K16/28; G01N33/68; G01N33/74; (IPC1-7): G01N33/53
Foreign References:
| JP2003337131A | 2003-11-28 | |||
| JPH08103280A | 1996-04-23 |
Other References:
KANEZAKI, Y.: "Injection of the insulin receptor subunit increases blood glucose levels in mice", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 309, 2003, pages 572 - 577, XP004453637
KIKUCHI, K. ET AL.: "Saibo Seicho Inshi Receptor to Gan Idenshi Sanbutsu (II) Insulin Receptor", PROTEIN, NUCLEIC ACID AND ENZYME, vol. 30, no. 13, 1985, pages 1388 - 1393, XP002986801
FRODE, T.S. ET AL.: "Tumour necrosis factor-alpha, interleukin-2 soluble receptor and different inflammatory parameters in patients with rheumatoid arthritis", MEDIATORS INFLAMM., vol. 11, no. 6, December 2002 (2002-12-01), pages 345 - 9
BARON, A.T. ET AL.: "Soluble Epidermal Growth Factor Receptor (sEGFRÔäôsErbB1) as a potential Risk, Screening, and Diagnostic Serum Biomarkerof Epithelial Ovarian Cancer", CANCER EPIDEMIOL BIOMARKERS PREV., vol. 12, no. 2, February 2003 (2003-02-01), pages 103 - 13
BEGUIN, Y.: "Soluble transferrin receptor for the evaluation of erythropoiesis and iron status", CLIN. CHEM. ACTA., vol. 329, no. 1-2, March 2003 (2003-03-01), pages 9 - 22
ERIK M. SCHAEFER ET AL., DIABETES, vol. 43, 1994, pages 143 - 153
PEZZINO, JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, 1992
APOSTOLOPOULOU ET AL., ACTA CYTOLOGICAL, 2002
NAESER, UPSALA J. MED. SCI., 1997
ROSENZWEIG ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, 1990
HEFFETZ; ZICK, JOURNAL OF BIOLOGICAL CHEMISTRY, 1986
LI ET AL., JOURNAL OF ENDOCRINOLOGY AND METABOLISM, 2002
SESTI ET AL., DIABETOLOGIA, 1995
CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, 1987
See also references of EP 1624305A4
KIKUCHI, K. ET AL.: "Saibo Seicho Inshi Receptor to Gan Idenshi Sanbutsu (II) Insulin Receptor", PROTEIN, NUCLEIC ACID AND ENZYME, vol. 30, no. 13, 1985, pages 1388 - 1393, XP002986801
FRODE, T.S. ET AL.: "Tumour necrosis factor-alpha, interleukin-2 soluble receptor and different inflammatory parameters in patients with rheumatoid arthritis", MEDIATORS INFLAMM., vol. 11, no. 6, December 2002 (2002-12-01), pages 345 - 9
BARON, A.T. ET AL.: "Soluble Epidermal Growth Factor Receptor (sEGFRÔäôsErbB1) as a potential Risk, Screening, and Diagnostic Serum Biomarkerof Epithelial Ovarian Cancer", CANCER EPIDEMIOL BIOMARKERS PREV., vol. 12, no. 2, February 2003 (2003-02-01), pages 103 - 13
BEGUIN, Y.: "Soluble transferrin receptor for the evaluation of erythropoiesis and iron status", CLIN. CHEM. ACTA., vol. 329, no. 1-2, March 2003 (2003-03-01), pages 9 - 22
ERIK M. SCHAEFER ET AL., DIABETES, vol. 43, 1994, pages 143 - 153
PEZZINO, JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, 1992
APOSTOLOPOULOU ET AL., ACTA CYTOLOGICAL, 2002
NAESER, UPSALA J. MED. SCI., 1997
ROSENZWEIG ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, 1990
HEFFETZ; ZICK, JOURNAL OF BIOLOGICAL CHEMISTRY, 1986
LI ET AL., JOURNAL OF ENDOCRINOLOGY AND METABOLISM, 2002
SESTI ET AL., DIABETOLOGIA, 1995
CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, 1987
See also references of EP 1624305A4
Attorney, Agent or Firm:
Shimizu, Hatsushi (Oroshi-machi Tsuchiura-shi, Ibaraki, JP)
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