Title:
METHOD FOR PRODUCING cis,cis-1,2,4-CYCLOHEXANE TRICARBOXYLIC ACID CRYSTAL
Document Type and Number:
WIPO Patent Application WO/2018/180696
Kind Code:
A1
Abstract:
The object of the present invention is to provide a method for producing a cis,cis-1,2,4-cyclohexane tricarboxylic acid crystal, wherein a high purity cis,cis-1,2,4-cyclohexane tricarboxylic acid crystal is obtained. This method for producing a cis,cis-1,2,4-cyclohexane tricarboxylic acid crystal comprises the following steps: step 1, a step for measuring the mass ratio (cis/trans ratio) of cis,cis-1,2,4-cyclohexane tricarboxylic acid to trans,trans-1,2,4-cyclohexane tricarboxylic acid in a raw aqueous solution containing the cis,cis-1,2,4-cyclohexane tricarboxylic acid to obtain a crystallization aqueous solution having a cis/trans ratio of at least 10; and step 2, a step for crystallizing the crystallization aqueous solution obtained from step 1.
Inventors:
SAITO SHINYA (JP)
KUMANO TATSUYUKI (JP)
KUMANO TATSUYUKI (JP)
Application Number:
PCT/JP2018/010784
Publication Date:
October 04, 2018
Filing Date:
March 19, 2018
Export Citation:
Assignee:
MITSUBISHI GAS CHEMICAL CO (JP)
International Classes:
C07C51/43; C07C61/08
Domestic Patent References:
| WO2010010869A1 | 2010-01-28 |
Foreign References:
| US5412108A | 1995-05-02 | |||
| JP2013056856A | 2013-03-28 | |||
| US5412108A | 1995-05-02 | |||
| JP2009057385A | 2009-03-19 | |||
| JP2003286222A | 2003-10-10 |
Other References:
ISODA, SUMIRO ET AL.: "Medicinal chemical studies on antiplasmin drugs. VIII. 4-aminomethy lcyclohexanecarboxylic acid derivatives having a carboxyl or carboxymethyl group at C2", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 28, no. 8, 1980, pages 2337 - 2346, XP002309738
OMICHI, YUJI ET AL.: "Optical Resolution of DL-Mandelic Acid by Preferential Crystallization Procedure", JOURNAL OF THE CHEMICAL SOCIETY OF JAPAN, January 1979 (1979-01-01), pages 1092 - 1096, XP055624842
NOHIRA, HIROYUKI: "Optical Resolution of Organic Compounds by Means of Crystallization and Their Applications", JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY, vol. 50, no. 1, 1 January 1992 (1992-01-01), Japan, pages 14 - 23, XP055624851, DOI: 10.5059/yukigoseikyokaishi.50.14
OKAMOTO, YOSHIO ET AL.: "Resolution of Enantiomers", CHEMISTRY & EDUCATION, vol. 43, no. 11, 1995, pages 695 - 699, XP009516293, DOI: 10.20665/kakyoshi.43.11_695t
See also references of EP 3604265A4
OMICHI, YUJI ET AL.: "Optical Resolution of DL-Mandelic Acid by Preferential Crystallization Procedure", JOURNAL OF THE CHEMICAL SOCIETY OF JAPAN, January 1979 (1979-01-01), pages 1092 - 1096, XP055624842
NOHIRA, HIROYUKI: "Optical Resolution of Organic Compounds by Means of Crystallization and Their Applications", JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY, vol. 50, no. 1, 1 January 1992 (1992-01-01), Japan, pages 14 - 23, XP055624851, DOI: 10.5059/yukigoseikyokaishi.50.14
OKAMOTO, YOSHIO ET AL.: "Resolution of Enantiomers", CHEMISTRY & EDUCATION, vol. 43, no. 11, 1995, pages 695 - 699, XP009516293, DOI: 10.20665/kakyoshi.43.11_695t
See also references of EP 3604265A4
Attorney, Agent or Firm:
OHTANI, Tamotsu (JP)
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