METHODS OF INHIBITING BINDING OF beta -SHEET FIBRIL TO RAGE AND CONSEQUENCES THEREOF

WIPO Patent Application WO2001012598

A3

This invention provides a method of inhibiting the binding of a beta -sheet fibril to RAGE on the surface of a cell which comprises contacting the cell with a binding inhibiting amount of a compound capable of inhibiting binding of the beta -sheet fibril to RAGE so as to thereby inhibit binding of the beta -sheet fibril to RAGE. In one embodiment the beta -sheet fibril is amyloid fibril. In one embodiment, the compound is sRAGE or a fragment thereof. In another embodiment, the compound is an anti-RAGE antibody or portion thereof. This invention provides the above method wherein the inhibition of binding of the beta -sheet fibril to RAGE has the consequences of decreasing the load of beta -sheet fibril in the tissue, inhibiting fibril-induced programmed cell death, inhibiting fibril-induced cell stress. This invention also provides methods of determining whether a compound inhibits binding of a beta -sheet fibril to RAGE on the surface of a cell.

STERN DAVID (US)
YAN SHI DU (US)
SCHMIDT ANN MARIE (US)

PCT/US2000/022059

January 17, 2002

August 11, 2000

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UNIV COLUMBIA (US)
STERN DAVID (US)
YAN SHI DU (US)
SCHMIDT ANN MARIE (US)

G01N33/53; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P1/02; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P13/12; A61P15/10; A61P17/00; A61P21/00; A61P25/00; A61P27/02; A61P29/00; A61P31/00; A61P35/00; A61P37/02; C07K14/47; C07K14/705; C07K16/28; C12N5/07; C12N5/074; C12N5/077; C12N5/0793; C12Q1/02; G01N33/68; C12R1/91; (IPC1-7): A61K39/00; A61K39/395; C07K5/00; C07K14/00; C07K16/00

WO1998044955A1	1998-10-15
WO1997039121A1	1997-10-23

US6100098A	2000-08-08
US5864018A	1999-01-26

See also references of EP 1307219A4

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