Title:
MACROCYCLE FOR INHIBITING AND INDUCING EGFR DEGRADATION AND PREPARATION METHOD FOR AND USE OF MACROCYCLE
Document Type and Number:
WIPO Patent Application WO/2024/017251
Kind Code:
A1
Abstract:
The present disclosure relates to a macrocycle for inhibiting and inducing EGFR degradation and a preparation method for and a use of the macrocycle. Specifically, the present disclosure relates to a macrocycle as shown in general formula (I) and a preparation method therefor, and a pharmaceutical composition containing the compound and a use thereof as a therapeutic agent, in particular to a use as an EGFR inhibitor and/or degrader and a use in preparation of a drug for treating and/or preventing EGFR-mediated or -dependent diseases or symptoms.
Inventors:
JIA MINQIANG (CN)
CHI JIANGTAO (CN)
HE FENG (CN)
TAO WEIKANG (CN)
CHI JIANGTAO (CN)
HE FENG (CN)
TAO WEIKANG (CN)
Application Number:
PCT/CN2023/107927
Publication Date:
January 25, 2024
Filing Date:
July 18, 2023
Export Citation:
Assignee:
JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D498/08; A61K31/495; A61P35/00; C07D239/70
Domestic Patent References:
| WO2021216440A1 | 2021-10-28 | |||
| WO2013126132A1 | 2013-08-29 | |||
| WO2021163627A1 | 2021-08-19 |
Foreign References:
| CN114394974A | 2022-04-26 | |||
| CN114656482A | 2022-06-24 |
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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