MACROCYCLIC DERIVATIVES AS FACTOR XIA INHIBITORS

Title:

MACROCYCLIC DERIVATIVES AS FACTOR XIA INHIBITORS

Document Type and Number:

WIPO Patent Application WO/2021/013209

Kind Code:

A1

Abstract:

Macrocyclic derivatives, preparation methods therefor and pharmaceutical compositions comprising said derivatives, and uses thereof as therapeutic agents, especially as factor XIa inhibitors and in drugs for treating and preventing thromboembolisms and other diseases. Specifically disclosed is a compound represented by formula (I), and an isomer and pharmaceutically acceptable salt thereof. (I)

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Inventors:

CAI YAXIAN (CN)
YAN XIAOBING (CN)
CAI ZHE (CN)
HU GUOPING (CN)
DING CHARLES Z (CN)
CHEN KEVIN X (CN)
LI JIAN (CN)
CHEN SHUHUI (CN)

Application Number:

PCT/CN2020/103692

Publication Date:

January 28, 2021

Filing Date:

July 23, 2020

Export Citation:

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Assignee:

MEDSHINE DISCOVERY INC (CN)

International Classes:

C07D471/18; A61K31/439; A61P7/02; A61P9/10; C07D487/18

Domestic Patent References:

WO2018133793A1	2018-07-26
WO2011100401A1	2011-08-18
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Foreign References:

CN108430471A	2018-08-21
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Other References: