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Patent Searching and Data


Title:
MACROCYCLIC INDOLES AS MCL-1 INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2020/103864
Kind Code:
A1
Abstract:
Disclosed is compound of formula I and the pharmaceutically acceptable salts and solvates thereof, wherein R, R1a, R1b, R1h, L1, L2, L3, Ⓐ, Ⓑ, Ⓒ are as defined as set forth in the specification. Disclosed is compound of formula I for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer.

Inventors:
CHEN HAO (CN)
CHEN WENMING (CN)
LI CHAO (CN)
LI DONGBO (CN)
JING YU (CN)
TANG GUOZHI (CN)
ZHOU YUNLONG (CN)
WANG SHAOMENG (US)
YANG CHAO-YIE (US)
Application Number:
CN2019/119698
Publication Date:
May 28, 2020
Filing Date:
November 20, 2019
Export Citation:
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Assignee:
ASCENTAGE PHARMA SUZHOU CO LTD (CN)
UNIV MICHIGAN REGENTS (US)
ASCENTAGE PHARMA GROUP CORP LTD (CN)
International Classes:
C07D497/22; A61K31/395; A61P35/00; C07D231/12; C07D515/22
Domestic Patent References:
WO2018178226A12018-10-04
WO2018178226A12018-10-04
WO2018178227A12018-10-04
WO2018178227A12018-10-04
Foreign References:
US20170305926A12017-10-26
US20170305926A12017-10-26
CN106456602A2017-02-22
CN106456602A2017-02-22
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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