Title:
MACROCYCLIC PEPTIDOMIMETIC PROTEASE INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/008044
Kind Code:
A1
Abstract:
A compound, which is a compound represented by formula (I) or a stereoisomer, tautomer, nitrogen oxide, solvate, metabolite, pharmaceutically acceptable salt or prodrug thereof. The compound represented by formula (I) can significantly inhibit Mpro or inhibit coronavirus replication, and has good metabolic stability.
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| WO/1994/011018 | OPIOID PEPTIDES |
Inventors:
YU YANG (CN)
XUE DING (CN)
LIU WEI (CN)
XUE DING (CN)
LIU WEI (CN)
Application Number:
PCT/CN2023/105562
Publication Date:
January 11, 2024
Filing Date:
July 03, 2023
Export Citation:
Assignee:
TENCENT TECH SHENZHEN CO LTD (CN)
International Classes:
C07K5/027; A61K31/407; A61P31/14; C07D491/20; C07K5/097
Domestic Patent References:
| WO2007001406A2 | 2007-01-04 | |||
| WO2022013684A1 | 2022-01-20 |
Foreign References:
| US20220380377A1 | 2022-12-01 | |||
| CN114805478A | 2022-07-29 | |||
| CN114426568A | 2022-05-03 | |||
| US20220062232A1 | 2022-03-03 |
Other References:
OWEN DAFYDD R., ALLERTON CHARLOTTE M. N., ANDERSON ANNALIESA S., ASCHENBRENNER LISA, AVERY MELISSA, BERRITT SIMON, BORAS BRITTON, : "An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 374, no. 6575, 24 December 2021 (2021-12-24), US , pages 1586 - 1593, XP093025782, ISSN: 0036-8075, DOI: 10.1126/science.abl4784
ELIEL, EWILEN, S.: "Stereochemistry of Organic Compounds", 1994, JOHN WILEY & SONS, INC.
THOMAS SORRELL: "Organic Chemistry", 1999, UNIVERSITY SCIENCE BOOKS
MICHAEL B. SMITHJERRY MARCH: "March's Advanced Organic Chemistry", 2007, JOHN WILEY & SONS
"Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
L. W. DEADY, SYN. COMM, vol. 7, 1977, pages 509 - 514
S. M. BERGE ET AL., J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 1 - 19
T. HIGUCHIV STELLA: "Pro-drugs as Novel Delivery Systems", A.C.S. SYMPOSIUM SERIES, vol. 14
"American Pharmaceutical Association", 1987, PERGAMON PRESS, article "Bioreversible Carriers in Drug Design"
J. RAUTIO ET AL.: "Prodrugs: Design and Clinical Applications", NATURE REVIEW DRUG DISCOVERY, vol. 7, 2008, pages 255 - 270, XP055227338, DOI: 10.1038/nrd2468
S. J. HECKER ET AL.: "Prodrugs of Phosphates and Phosphonates", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, 2008, pages 2328 - 2345, XP008148502, DOI: 10.1021/jm701260b
JACQUES ET AL.: "Enantiomers, Racemates and Resolutions", 1981, WILEY INTERSCIENCE
"Principles of Asymmetric Synthesis", 2012, ELSEVIER
ELIEL, E.L: "Stereochemistry of Carbon Compounds", 1962, MCGRAW-HILL
WILEN, S.H: "Tables of Resolving Agents and Optical Resolutions", 1972, UNIV. OF NOTRE DAME PRESS, pages: 268
"Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY, pages: 1289 - 1329
T W. GREENE: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY&SONS
P. J. KOCIENSKI, PROTECTING GROUPS, 2005
"Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
"Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT WILLIAMS & WILKINS
"Encyclopedia of Pharmaceutical Technology", 1988, MARCEL DEKKER
ELIEL, EWILEN, S.: "Stereochemistry of Organic Compounds", 1994, JOHN WILEY & SONS, INC.
THOMAS SORRELL: "Organic Chemistry", 1999, UNIVERSITY SCIENCE BOOKS
MICHAEL B. SMITHJERRY MARCH: "March's Advanced Organic Chemistry", 2007, JOHN WILEY & SONS
"Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
L. W. DEADY, SYN. COMM, vol. 7, 1977, pages 509 - 514
S. M. BERGE ET AL., J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 1 - 19
T. HIGUCHIV STELLA: "Pro-drugs as Novel Delivery Systems", A.C.S. SYMPOSIUM SERIES, vol. 14
"American Pharmaceutical Association", 1987, PERGAMON PRESS, article "Bioreversible Carriers in Drug Design"
J. RAUTIO ET AL.: "Prodrugs: Design and Clinical Applications", NATURE REVIEW DRUG DISCOVERY, vol. 7, 2008, pages 255 - 270, XP055227338, DOI: 10.1038/nrd2468
S. J. HECKER ET AL.: "Prodrugs of Phosphates and Phosphonates", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, 2008, pages 2328 - 2345, XP008148502, DOI: 10.1021/jm701260b
JACQUES ET AL.: "Enantiomers, Racemates and Resolutions", 1981, WILEY INTERSCIENCE
"Principles of Asymmetric Synthesis", 2012, ELSEVIER
ELIEL, E.L: "Stereochemistry of Carbon Compounds", 1962, MCGRAW-HILL
WILEN, S.H: "Tables of Resolving Agents and Optical Resolutions", 1972, UNIV. OF NOTRE DAME PRESS, pages: 268
"Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY, pages: 1289 - 1329
T W. GREENE: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY&SONS
P. J. KOCIENSKI, PROTECTING GROUPS, 2005
"Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
"Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT WILLIAMS & WILKINS
"Encyclopedia of Pharmaceutical Technology", 1988, MARCEL DEKKER
Attorney, Agent or Firm:
BEIJING LISENG INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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