Title:
MACROPHAGES DERIVED FROM INDUCED PLURIPOTENT STEM CELLS, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/249396
Kind Code:
A1
Abstract:
The present invention provides: a method for preparing macrophages derived from induced pluripotent stem cells; and macrophages derived from induced pluripotent stem cells, prepared by the preparation method, the method comprising the steps of: (a) preparing haemopoietic precursor cells from induced pluripotent stem cells; (b) inducing monocytes from the haemopoietic precursor cells prepared in step (a); and (c) differentiating, into macrophages, the monocytes induced in step (b).
Inventors:
LEE MI YEON (KR)
NA DEUK CHAE (KR)
KIM KYOUNG WOON (KR)
LEE KYUNG A (KR)
NA DEUK CHAE (KR)
KIM KYOUNG WOON (KR)
LEE KYUNG A (KR)
Application Number:
PCT/KR2023/008582
Publication Date:
December 28, 2023
Filing Date:
June 21, 2023
Export Citation:
Assignee:
ONCOINSIGHT CO LTD (KR)
International Classes:
C12N5/0786; A61K35/15; A61P35/00
Foreign References:
| KR102269240B1 | 2021-06-25 |
Other References:
CAO XU, YAKALA GOPALA K., VAN DEN HIL FRANCIJNA E., COCHRANE AMY, MUMMERY CHRISTINE L., ORLOVA VALERIA V.: "Differentiation and Functional Comparison of Monocytes and Macrophages from hiPSCs with Peripheral Blood Derivatives", STEM CELL REPORTS, CELL PRESS, UNITED STATES, vol. 12, no. 6, 1 June 2019 (2019-06-01), United States , pages 1282 - 1297, XP055838672, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2019.05.003
ANONYMOUS: "Hematopoietic stem and progenitor cells products for your research. ", STEMCELL TECHNOLOGIES INC., 16 September 2019 (2019-09-16), pages 1 - 39, XP093118703, Retrieved from the Internet [retrieved on 20240112]
PILLING DARRELL, GALVIS-CARVAJAL ELKIN, KARHADKAR TEJAS R., COX NEHEMIAH, GOMER RICHARD H.: "Monocyte differentiation and macrophage priming are regulated differentially by pentraxins and their ligands", BMC IMMUNOLOGY, BIOMED CENTRAL, LONDON, GB, vol. 18, no. 1, 1 December 2017 (2017-12-01), GB , XP093118707, ISSN: 1471-2172, DOI: 10.1186/s12865-017-0214-z
LYADOVA IRINA, GERASIMOVA TATIANA, NENASHEVA TATIANA: "Macrophages Derived From Human Induced Pluripotent Stem Cells: The Diversity of Protocols, Future Prospects, and Outstanding Questions", FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, FRONTIERS MEDIA, CH, vol. 9, 2 June 2021 (2021-06-02), CH , pages 640703, XP093118709, ISSN: 2296-634X, DOI: 10.3389/fcell.2021.640703
LI SHANSHAN, SONG LILI, ZHANG YINGWEN, ZHAN ZHIYAN, YANG YI, YU LISHA, ZHU HUA, HUANG WEIHUA, WANG WANQIAO, FENG HAIZHONG, LI YANX: "Optimizing the Method for Differentiation of Macrophages from Human Induced Pluripotent Stem Cells", STEM CELLS INTERNATIONAL, HINDAWI PUBLISHING CORPORATION, US, vol. 2022, 3 March 2022 (2022-03-03), US , pages 1 - 13, XP093118712, ISSN: 1687-966X, DOI: 10.1155/2022/6593403
ANONYMOUS: "Hematopoietic stem and progenitor cells products for your research. ", STEMCELL TECHNOLOGIES INC., 16 September 2019 (2019-09-16), pages 1 - 39, XP093118703, Retrieved from the Internet
PILLING DARRELL, GALVIS-CARVAJAL ELKIN, KARHADKAR TEJAS R., COX NEHEMIAH, GOMER RICHARD H.: "Monocyte differentiation and macrophage priming are regulated differentially by pentraxins and their ligands", BMC IMMUNOLOGY, BIOMED CENTRAL, LONDON, GB, vol. 18, no. 1, 1 December 2017 (2017-12-01), GB , XP093118707, ISSN: 1471-2172, DOI: 10.1186/s12865-017-0214-z
LYADOVA IRINA, GERASIMOVA TATIANA, NENASHEVA TATIANA: "Macrophages Derived From Human Induced Pluripotent Stem Cells: The Diversity of Protocols, Future Prospects, and Outstanding Questions", FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, FRONTIERS MEDIA, CH, vol. 9, 2 June 2021 (2021-06-02), CH , pages 640703, XP093118709, ISSN: 2296-634X, DOI: 10.3389/fcell.2021.640703
LI SHANSHAN, SONG LILI, ZHANG YINGWEN, ZHAN ZHIYAN, YANG YI, YU LISHA, ZHU HUA, HUANG WEIHUA, WANG WANQIAO, FENG HAIZHONG, LI YANX: "Optimizing the Method for Differentiation of Macrophages from Human Induced Pluripotent Stem Cells", STEM CELLS INTERNATIONAL, HINDAWI PUBLISHING CORPORATION, US, vol. 2022, 3 March 2022 (2022-03-03), US , pages 1 - 13, XP093118712, ISSN: 1687-966X, DOI: 10.1155/2022/6593403
Attorney, Agent or Firm:
GURU IP LAW FIRM (KR)
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