Title:
MAGNETOGENETICS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/035682
Kind Code:
A1
Abstract:
Provided is a non-invasive method of modulating the activity of a cell, comprising the steps of delivering a MAR gene into said cell and applying a magnetic stimulation to said cell. The medical use of magnetogenetics in treating diseases is also provided.
Inventors:
ZHANG SHENGJIA (CN)
Application Number:
PCT/CN2015/000622
Publication Date:
March 09, 2017
Filing Date:
August 31, 2015
Export Citation:
Assignee:
UNIV TSINGHUA (CN)
International Classes:
A61K48/00; A61N2/00; C07K14/435; C12N15/12
Domestic Patent References:
| WO2001071042A2 | 2001-09-27 |
Foreign References:
| EP1980628A2 | 2008-10-15 |
Other References:
IRENE ET AL.: "Co'zar-Castellano et al.,. ''hIscA: a protein implicated in the biogenesis of iron-sulfur clusters.", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1700, 9 June 2004 (2004-06-09), pages 179 - 188, XP004521486
WANG, DONGSHENG ET AL.: "Identification of interaction between ISCA1 and NLS-RARa by coimmunoprecipitation in mammalian cells.", J.FOURTH MILMED. UNIV., vol. 30, no. 06, 31 March 2009 (2009-03-31), pages 489 - 491, XP009504773
MANDILARAS, KONSTANTINOS ET AL.: "Genes for iron metabolism influence circadian rhythms in Drosophila melanogaster.", METALLOMICS., vol. 04, 31 December 2012 (2012-12-31), pages 928 - 936, XP055365492
BEINERT, HELMUT ET AL.: "Iron-Sulfur Clusters: Nature 's Modular, Multipurpose Structures.", SCIENCE, vol. 277, 1 August 1997 (1997-08-01), pages 653 - 658, XP055365494
See also references of EP 3344297A4
WANG, DONGSHENG ET AL.: "Identification of interaction between ISCA1 and NLS-RARa by coimmunoprecipitation in mammalian cells.", J.FOURTH MILMED. UNIV., vol. 30, no. 06, 31 March 2009 (2009-03-31), pages 489 - 491, XP009504773
MANDILARAS, KONSTANTINOS ET AL.: "Genes for iron metabolism influence circadian rhythms in Drosophila melanogaster.", METALLOMICS., vol. 04, 31 December 2012 (2012-12-31), pages 928 - 936, XP055365492
BEINERT, HELMUT ET AL.: "Iron-Sulfur Clusters: Nature 's Modular, Multipurpose Structures.", SCIENCE, vol. 277, 1 August 1997 (1997-08-01), pages 653 - 658, XP055365494
See also references of EP 3344297A4
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