Title:
MALARIA IMMUNOGEN AND VACCINE
Document Type and Number:
WIPO Patent Application WO2002013765
Kind Code:
A3
Abstract:
A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid protein (HBc) is disclosed that contains an immunogen for inducing the production of antibodies to malarial proteins. An immunogenic malarial epitope is expressed between residues 78 and 79 of the HBc immunogenic loop sequence. The chimer preferably contains a malaria-specific T cell epitope and is preferably engineered for both enhanced stability of self-assembled particles and enhanced yield of those chimeric particles. Methods of making and using the chimers are also disclosed.
Inventors:
BIRKETT ASHLEY J
Application Number:
PCT/US2001/025625
Publication Date:
July 25, 2002
Filing Date:
August 16, 2001
Export Citation:
Assignee:
APOVIA INC (US)
International Classes:
A61K39/015; A61P33/06; C07K14/445; C12N15/82; A61K; (IPC1-7): C07H21/02; C07H21/04; C12N15/00; C12N5/00; C12N15/63; C07K1/00; A01N63/00; A61K39/00; A61K39/12
Other References:
SCHOEDEL ET AL.: "Immunity to malaria elicited by hybrid hepatitis B virus core particles carrying circumsporozoite protein epitopes", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 180, September 1994 (1994-09-01), pages 1037 - 1046, XP000891465
ULRICH ET AL.: "Core particles of hepatitis B virus as carrier for foreign epitopes", ADVANCES IN VIRUS RESEARCH, vol. 50, 1998, pages 141 - 182, XP000856161
SCHOEDEL ET AL.: "Hybrid hepatitis B virus core antigen as a vaccine carrier moiety: I. presentation of foreign epitopes", JOURNAL OF BIOTECHNOLOGY, vol. 44, 1996, pages 91 - 96, XP000891474
ISAGULIANTS ET AL.: "Immunogenic combinations of HIV-1 B- and heterologous T-cell epitopes", IMMUNOLOGY LETTERS, vol. 42, 1994, pages 173 - 178, XP002909292
ULRICH ET AL.: "Core particles of hepatitis B virus as carrier for foreign epitopes", ADVANCES IN VIRUS RESEARCH, vol. 50, 1998, pages 141 - 182, XP000856161
SCHOEDEL ET AL.: "Hybrid hepatitis B virus core antigen as a vaccine carrier moiety: I. presentation of foreign epitopes", JOURNAL OF BIOTECHNOLOGY, vol. 44, 1996, pages 91 - 96, XP000891474
ISAGULIANTS ET AL.: "Immunogenic combinations of HIV-1 B- and heterologous T-cell epitopes", IMMUNOLOGY LETTERS, vol. 42, 1994, pages 173 - 178, XP002909292
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