MALARIA VACCINE AND MALARIA PREVENTION/TREATMENT METHOD

Title:

MALARIA VACCINE AND MALARIA PREVENTION/TREATMENT METHOD

Document Type and Number:

WIPO Patent Application WO/2023/157880

Kind Code:

A1

Abstract:

[Problem] To provide a malaria vaccine which has an excellent preventative effect against infection and excellent effect of inhibiting malaria transmission, as compared to conventional malaria vaccines. [Solution] It was found that using, as a prime, a recombinant vaccinia virus which includes a gene that codes a CSP amino acid sequence and a gene that codes an s25 amino acid sequence, and using, as a boost, a recombinant adeno-associated virus which includes a gene that codes a CSP amino acid sequence and a gene that codes an s25 amino acid sequence results in a malaria vaccine which has an excellent preventative effect against infection and excellent effect of inhibiting malaria transmission.

More Like This:

WO/2001/013923	MALARIA GPI ANCHORS AS VACCINES ANTI-PARASITIC DRUGS AND FOR USE IN DIAGNOSTICS
WO/2010/097709	POLYPEPTIDES FOR THE PREVENTION OR TREATMENT OF MALARIA
JP2005523908	Antigens and their use as diagnostics and vaccines against Plasmodium malaria species

Inventors:

SHIDA HISATOSHI (JP)
YOSHIDA SHIGETO (JP)
IYORI MITSUHIRO (JP)
MIZUKAMI HIROAKI (JP)

Application Number:

PCT/JP2023/005232

Publication Date:

August 24, 2023

Filing Date:

February 15, 2023

Export Citation:

Click for automatic bibliography generation Help

Assignee:

UNIV NAT CORP KANAZAWA (JP)
UNIV JICHI MEDICAL (JP)
SHIDA HISATOSHI (JP)

International Classes:

A61K39/015; A61K35/76; A61K39/23; A61K39/285; A61K48/00; A61P33/06; A61P37/04; A61P43/00; C12N7/01; C12N15/30; C12N15/863; C12N15/864

Domestic Patent References:

WO2007091624A1	2007-08-16
WO2016059911A1	2016-04-21

Foreign References:

JP2019151617A	2019-09-12
JP2010535466A	2010-11-25
JP2017512498A	2017-05-25
JP2017527293A	2017-09-21
JP2017502674A	2017-01-26

Other References:

BAUZA KAROLIS, MALINAUSKAS TOMAS, PFANDER CLAUDIA, ANAR BURCU, JONES E. YVONNE, BILLKER OLIVER, HILL ADRIAN V. S., REYES-SANDOVAL : "Efficacy of a Plasmodium vivax Malaria Vaccine Using ChAd63 and Modified Vaccinia Ankara Expressing Thrombospondin-Related Anonymous Protein as Assessed with Transgenic Plasmodium berghei Parasites", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 82, no. 3, 1 March 2014 (2014-03-01), US , pages 1277 - 1286, XP093084830, ISSN: 0019-9567, DOI: 10.1128/IAI.01187-13
HILL ADRIAN V S , REYES-SANDOVAL A, O'HARA G, ET AL: "Prime-boost vectored malaria vaccines: progress and prospects.", HUMAN VACCINES, LANDES BIOSCIENCE, GEORGETOWN, TX, US, vol. 6, no. 1, 1 January 2010 (2010-01-01), US , pages 78 - 83, XP002636116, ISSN: 1554-8600, DOI: 10.4161/hv.6.1.10116

Attorney, Agent or Firm:

SHOJI Takashi et al. (JP)

Download PDF:

View/Download PDF PDF Help

Previous Patent: WEAK-ANCHORING LIQUID CRYSTAL ALIGNING AGENT, AND LIQUID CRYSTAL DISPLAY ELEMENT

Next Patent: BARRIER LAMINATED FILM, LAMINATED FILM, LAMINATED BODY, AND PACKAGING CONTAINER