Title:
MALARIA VACCINE
Document Type and Number:
WIPO Patent Application WO/2016/059911
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a malaria vaccine exhibiting a higher protective effect than that of conventional malaria vaccines. The present invention was perfected due to the discovery that, after a recombinant virus other than a baculovirus that includes a gene encoding an amino acid sequence of a malaria antigen, plasmid DNA that has a gene encoding an amino acid sequence of this malaria antigen introduced thereto, or a protein that has an amino acid sequence of this malaria antigen is administered to a patient, administering to the patient a recombinant baculovirus that includes a gene encoding an amino acid sequence of this malaria antigen and a gene encoding an amino acid sequence of DAF results in a high protective effect being exhibited.
Inventors:
YOSHIDA SHIGETO (JP)
Application Number:
PCT/JP2015/075275
Publication Date:
April 21, 2016
Filing Date:
September 06, 2015
Export Citation:
Assignee:
UNIV KANAZAWA NAT UNIV CORP (JP)
International Classes:
A61K39/12; A61K39/015; A61P33/06; C12N7/00; C12N15/09
Domestic Patent References:
| WO2007091624A1 | 2007-08-16 | |||
| WO2007037265A1 | 2007-04-05 |
Foreign References:
| JP2010535466A | 2010-11-25 | |||
| JP2006512405A | 2006-04-13 | |||
| CN1357622A | 2002-07-10 | |||
| JP2003530064A | 2003-10-14 | |||
| JP2008516926A | 2008-05-22 |
Other References:
LASARTE J.J. ET AL.: "Different Doses of Adenoviral Vector Expressing IL -12 Enhance or Depress the Immune Response to a Coadministered Antigen: the Role of Nitric Oxide", J IMMUNOL, vol. 162, no. 6, 1999, pages 5270 - 5277, XP055275219, Retrieved from the Internet
IYORI MITSUHIRO ET AL.: "Protective Efficacy of Baculovirus Dual Expression System Vaccine Expressing Plasmodium falciparum Circumsporozoite Protein", PLOS ONE, vol. 8, no. 8, 12 August 2013 (2013-08-12), XP055162829, Retrieved from the Internet
YOSHIDA SHIGETO ET AL.: "A Baculovirus Dual Expression System-Based Malaria Vaccine Induces Strong Protection against Plasmodium berghei Sporozoite Challenge in Mice", INFECT. IMMUN., vol. 77, no. 5, May 2009 (2009-05-01), pages 1782 - 1789, XP009124531, Retrieved from the Internet
HUSER A. ET AL.: "Incorporation of decay-accelerating factor into the baculovirus envelope generates complement-resistant gene transfer vectors", NAT BIOTECHNOL., vol. 19, no. 5, May 2001 (2001-05-01), pages 451 - 455, XP002224592, Retrieved from the Internet
IYORI MITSUHIRO ET AL.: "Protective Efficacy of Baculovirus Dual Expression System Vaccine Expressing Plasmodium falciparum Circumsporozoite Protein", PLOS ONE, vol. 8, no. 8, 12 August 2013 (2013-08-12), XP055162829, Retrieved from the Internet
YOSHIDA SHIGETO ET AL.: "A Baculovirus Dual Expression System-Based Malaria Vaccine Induces Strong Protection against Plasmodium berghei Sporozoite Challenge in Mice", INFECT. IMMUN., vol. 77, no. 5, May 2009 (2009-05-01), pages 1782 - 1789, XP009124531, Retrieved from the Internet
HUSER A. ET AL.: "Incorporation of decay-accelerating factor into the baculovirus envelope generates complement-resistant gene transfer vectors", NAT BIOTECHNOL., vol. 19, no. 5, May 2001 (2001-05-01), pages 451 - 455, XP002224592, Retrieved from the Internet
Attorney, Agent or Firm:
SHOJI, Takashi et al. (JP)
Takashi Shoji (JP)
Takashi Shoji (JP)
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