Title:
MALARIA VACCINE
Document Type and Number:
WIPO Patent Application WO/2018/088509
Kind Code:
A1
Abstract:
The present invention provides a polypeptide and a malaria vaccine comprising said polypeptide, the polypeptide comprising any of the following amino acid sequences: (a) an amino acid sequence represented by SEQ ID NO. 4; (b) an amino acid sequence represented by SEQ ID NO. 4, in which 1-10, preferably 1-5, and more preferably 1-3 amino acids have been substituted, deleted, added or inserted; and (c) an amino acid sequence having at least 95%, preferably at least 97%, and more preferably at least 99% sequence identity with SEQ ID NO. 4.
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Inventors:
FUKUSHIMA AKIHISA (JP)
TSUBOI TAKAFUMI (JP)
TAKASHIMA EIZO (JP)
NAGAOKA HIKARU (JP)
TSUBOI TAKAFUMI (JP)
TAKASHIMA EIZO (JP)
NAGAOKA HIKARU (JP)
Application Number:
PCT/JP2017/040535
Publication Date:
May 17, 2018
Filing Date:
November 10, 2017
Export Citation:
Assignee:
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
UNIV NAT CORP EHIME UNIV (JP)
UNIV NAT CORP EHIME UNIV (JP)
International Classes:
C12N15/09; A61K39/015; A61K39/13; C07K14/445; C07K16/20; C07K17/02; C12N1/19; C12N1/21; C12N5/10; A61K39/05; A61K39/08; A61K39/10; A61P33/06; A61P37/04; A61P43/00
Domestic Patent References:
| WO2012046081A1 | 2012-04-12 | |||
| WO2015144874A1 | 2015-10-01 |
Other References:
ARUMUGAM, U. T. ET AL.: "Discovery of GAMA, a Plasmodium falciparum Merozoite Micronemal Protein, as a Novel Blood-Stage Vaccine Candidate Antigen", INFECTION AND IMMUNITY, vol. 79, no. 11, 6 September 2011 (2011-09-06), pages 4523 - 4532, XP055484651
HINDS, L. ET AL.: "Novel Putative Glycosylphosphatidylinositol-Anchored Micronemal Antigen of Plasmodium falciparum That Binds to Erythrocytes", EUKARYOTIC CELL, vol. 8, no. 12, 9 October 2009 (2009-10-09), pages 1869 - 1879, XP055484659
ITO, DAISUKE ET AL.: "RALP1 Is a Rhoptry Neck Erythrocyte-Binding Protein of Plasmodium falciparum Merozoites and a Potential Blood-Stage Vaccine Candidate Antigen", INFECTION AND IMMUNITY, vol. 81, no. 11, November 2013 (2013-11-01), pages 4290 - 4298, XP055484662
NTEGE, H. E. ET AL.: "Identification ofPlasmodium falciparumreticulocyte binding protein homologue 5-interacting protein, PfRipr, as a highly conserved blood-stage malaria vaccine candidate", VACCINE, vol. 34, 4 November 2016 (2016-11-04), pages 5612 - 5622, XP029772639
HINDS, L. ET AL.: "Novel Putative Glycosylphosphatidylinositol-Anchored Micronemal Antigen of Plasmodium falciparum That Binds to Erythrocytes", EUKARYOTIC CELL, vol. 8, no. 12, 9 October 2009 (2009-10-09), pages 1869 - 1879, XP055484659
ITO, DAISUKE ET AL.: "RALP1 Is a Rhoptry Neck Erythrocyte-Binding Protein of Plasmodium falciparum Merozoites and a Potential Blood-Stage Vaccine Candidate Antigen", INFECTION AND IMMUNITY, vol. 81, no. 11, November 2013 (2013-11-01), pages 4290 - 4298, XP055484662
NTEGE, H. E. ET AL.: "Identification ofPlasmodium falciparumreticulocyte binding protein homologue 5-interacting protein, PfRipr, as a highly conserved blood-stage malaria vaccine candidate", VACCINE, vol. 34, 4 November 2016 (2016-11-04), pages 5612 - 5622, XP029772639
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
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