Title:
MAMMALIAN EXPRESSION OF THE BMP-2 FAMILY
Document Type and Number:
WIPO Patent Application WO1991018047
Kind Code:
A3
Abstract:
A DNA construct is provided comprising DNA encoding a mature BMP-2 upstream of which is DNA encoding a precursor portion of a mammalian protein other than the BMP-2. Also provided are mammalian expression vectors and hosts containing such a DNA construct and methods for improved expression using such construct.
Inventors:
HAMMONDS R GLENN (US)
MASON ANTHONY J (US)
MASON ANTHONY J (US)
Application Number:
PCT/US1991/003540
Publication Date:
April 02, 1992
Filing Date:
May 20, 1991
Export Citation:
Assignee:
GENENTECH INC (US)
International Classes:
C07K14/51; C12N5/10; C12N1/21; C12N15/09; C12N15/12; C12P21/02; C12R1/19; C12R1/91; (IPC1-7): C08J7/18; C08K7/02
Foreign References:
| US3676401A | 1972-07-11 | |||
| US3860538A | 1975-01-14 | |||
| CA1073581A | 1980-03-11 | |||
| US4495311A | 1985-01-22 |
Other References:
See also references of EP 0531448A1
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