Title:
MAMMALIAN GENES PARTICIPATING IN CIRCADIAN PERIOD
Document Type and Number:
WIPO Patent Application WO/1999/014324
Kind Code:
A1
Abstract:
A human gene and a mouse gene corresponding to $i(Drosophila) period gene which has been known as participating in the circadian period. The proteins and DNAs are applicable to the treatment of diseases relating to the circadian rhythm such as sleep stage regression syndrome, sleep stage progression syndrome, non-circadian agrypnotic syndrome, irregular agrypnotic disorder and time difference syndrome (i.e., so-called jet lag), labor and health management of those working until late at night irregularly, prevention of night poriomania in dementia, etc.
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Inventors:
SAKAKI YOSHIYUKI (JP)
TEI HAJIME (JP)
TEI HAJIME (JP)
Application Number:
PCT/JP1998/004125
Publication Date:
March 25, 1999
Filing Date:
September 11, 1998
Export Citation:
Assignee:
SAKAKI YOSHIYUKI (JP)
TEI HAJIME (JP)
TEI HAJIME (JP)
International Classes:
C07K14/47; C12N15/12; A61K38/00; (IPC1-7): C12N15/12; C07K14/47; C12N5/18; C12N15/63; C12P21/00
Other References:
SUN Z. S., ET AL.: "RIGUI, A PUTATIVE MAMMALIAN ORTHOLOG OF THE DROSOPHILA PERIOD GENE.", CELL, CELL PRESS, US, vol. 90., no. 06., 19 September 1997 (1997-09-19), US, pages 1003 - 1011., XP002915075, ISSN: 0092-8674, DOI: 10.1016/S0092-8674(00)80366-9
TEI H., ET AL.: "CIRCADIAN OSCILLATION OF A MAMMALIAN HOMOLOGUE OF THE DROSOPHILA PERIOD GENE.", NATURE, NATURE PUBLISHING GROUP, UNITED KINGDOM, vol. 389., no. 6650., 2 October 1997 (1997-10-02), United Kingdom, pages 512 - 516., XP002915076, ISSN: 0028-0836, DOI: 10.1038/39086
ALBRECHT U., ET AL.: "A DIFFERENTIAL RESPONSE OF TWO PUTATIVE MAMMALIAN CIRCADIAN REGULATORS, MPER1 AND MPER2, TO LIGHT.", CELL, CELL PRESS, US, vol. 91., no. 07., 26 December 1997 (1997-12-26), US, pages 1055 - 1064., XP002915077, ISSN: 0092-8674, DOI: 10.1016/S0092-8674(00)80495-X
TEI H., ET AL.: "CIRCADIAN OSCILLATION OF A MAMMALIAN HOMOLOGUE OF THE DROSOPHILA PERIOD GENE.", NATURE, NATURE PUBLISHING GROUP, UNITED KINGDOM, vol. 389., no. 6650., 2 October 1997 (1997-10-02), United Kingdom, pages 512 - 516., XP002915076, ISSN: 0028-0836, DOI: 10.1038/39086
ALBRECHT U., ET AL.: "A DIFFERENTIAL RESPONSE OF TWO PUTATIVE MAMMALIAN CIRCADIAN REGULATORS, MPER1 AND MPER2, TO LIGHT.", CELL, CELL PRESS, US, vol. 91., no. 07., 26 December 1997 (1997-12-26), US, pages 1055 - 1064., XP002915077, ISSN: 0092-8674, DOI: 10.1016/S0092-8674(00)80495-X
Attorney, Agent or Firm:
Shimizu, Hatsushi (Oroshi-machi Tsuchiura-shi Ibaraki, JP)
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