Title:
MANUFACTURING METHOD FOR FP-CIT PRECURSOR, AND MANUFACTURING METHOD FOR [18F]FP-CIT USING FP-CIT PRECURSOR MANUFACTURED THEREBY
Document Type and Number:
WIPO Patent Application WO/2023/219199
Kind Code:
A1
Abstract:
Disclosed are a manufacturing method for a FP-CIT precursor, and a manufacturing method for [18F]FP-CIT using a FP-CIT precursor manufactured thereby. The manufacturing method for a FP-CIT precursor, according to one embodiment of the present invention, comprises obtaining a compound of chemical formula 1, a compound of chemical formula 1-1, and a compound of chemical formula 2 from tropinone through pure organic synthesis.
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Inventors:
HA HYUN JOON (KR)
MACHA LINGAMURTHY (KR)
KIM JONG WOO (KR)
MACHA LINGAMURTHY (KR)
KIM JONG WOO (KR)
Application Number:
PCT/KR2022/007221
Publication Date:
November 16, 2023
Filing Date:
May 20, 2022
Export Citation:
Assignee:
DUCHEMBIO CO LTD (KR)
International Classes:
C07D451/02; C07B59/00
Foreign References:
| KR20120038156A | 2012-04-23 | |||
| KR102063498B1 | 2020-01-08 | |||
| US20100292478A1 | 2010-11-18 |
Other References:
JOHN L. NEUMEYER, GILLES TAMAGNAN, SHAOYIN WANG, YIGONG GAO, RICHARD A. MILIUS, NORA S. KULA, AND ROSS J. BALDESSARINI: "N-SUBSTITUTED ANALOGS OF 2BETA-CARBOMETHOXY-3BETA-(4'-IODOPHENYL) TROPANE ( BETA-CIT) WITH SELECTIVE AFFINITY TO DOPAMINE OR SEROTONIN TRANSPORTERS IN RAT FOREBRAIN", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 39, 1 January 1996 (1996-01-01), US , pages 543 - 548, XP001051290, ISSN: 0022-2623, DOI: 10.1021/jm9505324
LEE, S.J. OH, S.J. CHI, D.Y. KANG, S.H. KIL, H.S. KIM, J.S. MOON, D.H.: "One-step high-radiochemical-yield synthesis of [^1^8F]FP-CIT using a protic solvent system", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER, NY., US, vol. 34, no. 4, 1 May 2007 (2007-05-01), US , pages 345 - 351, XP022097721, ISSN: 0969-8051, DOI: 10.1016/j.nucmedbio.2007.02.007
LEE, S.J. OH, S.J. CHI, D.Y. KANG, S.H. KIL, H.S. KIM, J.S. MOON, D.H.: "One-step high-radiochemical-yield synthesis of [^1^8F]FP-CIT using a protic solvent system", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER, NY., US, vol. 34, no. 4, 1 May 2007 (2007-05-01), US , pages 345 - 351, XP022097721, ISSN: 0969-8051, DOI: 10.1016/j.nucmedbio.2007.02.007
Attorney, Agent or Firm:
HAN, Seung Beom (KR)
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