Title:
MANUFACTURING METHOD FOR HIGH-PURITY CYCLOHEXENONE LONG-CHAIN ALCOHOL
Document Type and Number:
WIPO Patent Application WO/2017/125087
Kind Code:
A1
Abstract:
The present invention relates to a manufacturing method for a high-purity cyclohexenone long-chain alcohol compound represented by formula (I). The manufacturing method for the compound represented by formula (I) adopts a metal-induced Barbier reaction. The invention has the advantages of a short reaction path, high yield, and high product purity, and is suitable for scaling up industrially.
Inventors:
ZHANG JIAN (CN)
JIANG DEHUI (CN)
SHEN XIAOJUN (CN)
JIANG DEHUI (CN)
SHEN XIAOJUN (CN)
Application Number:
PCT/CN2017/072078
Publication Date:
July 27, 2017
Filing Date:
January 22, 2017
Export Citation:
Assignee:
TAIHO PHARMACEUTICAL CO LTD (JP)
International Classes:
C07C49/753
Other References:
HUBER, TATJANA ET AL.: "Experimental Studies on the Selective beta -C-H Halogenation of Enones", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 80, no. 4, 26 January 2015 (2015-01-26), pages 2281 - 2294, XP055400738, ISSN: 0022-3263
SHIRINI, FARHAD ET AL.: "Efficient Oxidative Cleavage of C=N Using Chromium Trioxide Supported on NaHSO4.H2O", ARKIVOC, 31 December 2007 (2007-12-31), pages 34 - 39, XP055532363, ISSN: 1424-6376
LEVINE, SAMANTHA R. ET AL.: "Catalytic Enantioselective Approach to the Eudesmane Sesquiterpenoids: Total Synthesis of (+)-Carissone", ORGANIC LETTERS, vol. 11, no. 2, 15 January 2009 (2009-01-15), pages 289 - 292, XP055532366, ISSN: 1523-7060
LUMB, ANSHIKA ET AL.: "A Simple, Mild and Environmentally Benign Procedure for the Cleavage of Carbon-Nitrogen Double Bonds Using NaBr03 in the Presence of [Bmim] HS04", ROYAL SOCIETY OF CHEMISTRY ADVANCES, vol. 4, 17 September 2014 (2014-09-17), pages 47677 - 47689, XP055400751, ISSN: 2046-2069
KIM, SANG-WON ET AL.: "Vinylogous Intramolecular Nucleophilic Acyl Substitution Reactions Mediated by Samarium(II) Iodide", BULLETIN OF THE KOREAN CHEMICAL SOCIETY, vol. 21, no. 12, 25 August 2000 (2000-08-25), pages 1175 - 1176, XP055532368, ISSN: 0253-2964
See also references of EP 3406586A4
SHIRINI, FARHAD ET AL.: "Efficient Oxidative Cleavage of C=N Using Chromium Trioxide Supported on NaHSO4.H2O", ARKIVOC, 31 December 2007 (2007-12-31), pages 34 - 39, XP055532363, ISSN: 1424-6376
LEVINE, SAMANTHA R. ET AL.: "Catalytic Enantioselective Approach to the Eudesmane Sesquiterpenoids: Total Synthesis of (+)-Carissone", ORGANIC LETTERS, vol. 11, no. 2, 15 January 2009 (2009-01-15), pages 289 - 292, XP055532366, ISSN: 1523-7060
LUMB, ANSHIKA ET AL.: "A Simple, Mild and Environmentally Benign Procedure for the Cleavage of Carbon-Nitrogen Double Bonds Using NaBr03 in the Presence of [Bmim] HS04", ROYAL SOCIETY OF CHEMISTRY ADVANCES, vol. 4, 17 September 2014 (2014-09-17), pages 47677 - 47689, XP055400751, ISSN: 2046-2069
KIM, SANG-WON ET AL.: "Vinylogous Intramolecular Nucleophilic Acyl Substitution Reactions Mediated by Samarium(II) Iodide", BULLETIN OF THE KOREAN CHEMICAL SOCIETY, vol. 21, no. 12, 25 August 2000 (2000-08-25), pages 1175 - 1176, XP055532368, ISSN: 0253-2964
See also references of EP 3406586A4
Attorney, Agent or Firm:
SHANGCHENG & PARTNERS (CN)
Download PDF: