Title:
MARBURG VIRUS VACCINES
Document Type and Number:
WIPO Patent Application WO2000000616
Kind Code:
A3
Abstract:
Using the MBGV GP, NP and virion proteins, a method and composition for use in inducing an immune response which is protective against infection with MBGV in nonhuman primates is described.
Inventors:
HEVEY MICHAEL C (US)
NEGLEY DIANE L (US)
PUSHKO PETER (US)
SMITH JONATHAN F (US)
SCHMALJOHN ALAN L (US)
NEGLEY DIANE L (US)
PUSHKO PETER (US)
SMITH JONATHAN F (US)
SCHMALJOHN ALAN L (US)
Application Number:
PCT/US1999/014174
Publication Date:
July 06, 2000
Filing Date:
June 21, 1999
Export Citation:
Assignee:
US MED RES INST INFECT DISEASE (US)
HEVEY MICHAEL C (US)
NEGLEY DIANE L (US)
PUSHKO PETER (US)
SMITH JONATHAN F (US)
SCHMALJOHN ALAN L (US)
HEVEY MICHAEL C (US)
NEGLEY DIANE L (US)
PUSHKO PETER (US)
SMITH JONATHAN F (US)
SCHMALJOHN ALAN L (US)
International Classes:
C07K14/08; C07K14/18; C12N7/00; C12N7/04; C12N15/40; C12N15/86; A61K38/00; A61K39/00; (IPC1-7): C12N15/40; C12N15/86; C12N7/01; C07K14/08; A61K39/12
Domestic Patent References:
| WO1996037616A1 | 1996-11-28 |
Other References:
C. WILL ET AL.: "Marburg virus gene encodes for the virion mmebrane protein, a type I transmembrane glycoprotein", J. VIROLOGY, vol. 67, no. 3, March 1993 (1993-03-01), AM.SOC.MICROBIOL.,WASHINGTON,US, pages 1203 - 1210, XP002128205
A.A. BUKREYEV ET AL.: "The GP-protein of Marburg virus contains the region similar to the 'immunosuppressive domain' of oncogenic retrovirus P15E protein", FEBS LETTERS, vol. 323, no. 1,2, May 1993 (1993-05-01), ELSEVIER, AMSTERDAM, NL, pages 183 - 187, XP002128206
M. HEVEY ET AL.: "Antigenicity and vaccine potential of Marburg virus glycoprotein expressed by baculovirus recombinnats", VIROLOGY, vol. 239, 1997, ACADEMIC PRESS, INC.,NEW YORK, US, pages 206 - 216, XP002128207
SANCHEZ A ET AL: "SEQUENCE ANALYSIS OF THE EBOLA VIRUS GENOME: ORGANIZATION, GENETIC ELEMENTS, AND COMPARISON WITH THE GENOME OF MARBURG VIRUS", VIRUS RESEARCH,NL,AMSTERDAM, vol. 29, no. 3, pages 215-240, XP000198438, ISSN: 0168-1702
A. SANCHEZ ET AL.: "Variation in the glycoprotein and VP35 genes of Marburg virus strains", VIROLOGY, vol. 240, no. 1, 5 January 1998 (1998-01-05), ACADEMIC PRESS, INC.,NEW YORK, US, pages 138 - 146, XP002128208
P. PUSHKO ET AL.: "Replicon-helper systems from attenuated Venezuelan equine encephalitis virus: Expression of heterologous genes in vitro and imunization against heterologous pathogens in vivo", VIROLOGY, vol. 239, 1997, ACADEMIC PRESS, INC.,NEW YORK, US, pages 389 - 401, XP002128209
HEVEY M ET AL: "Marburg virus vaccines based upon alphavirus replicons protect guinea pigs and nonhuman primates.", VIROLOGY, (1998 NOV 10) 251 (1) 28-37. JOURNAL CODE: XEA., XP002128210
A.A. BUKREYEV ET AL.: "The GP-protein of Marburg virus contains the region similar to the 'immunosuppressive domain' of oncogenic retrovirus P15E protein", FEBS LETTERS, vol. 323, no. 1,2, May 1993 (1993-05-01), ELSEVIER, AMSTERDAM, NL, pages 183 - 187, XP002128206
M. HEVEY ET AL.: "Antigenicity and vaccine potential of Marburg virus glycoprotein expressed by baculovirus recombinnats", VIROLOGY, vol. 239, 1997, ACADEMIC PRESS, INC.,NEW YORK, US, pages 206 - 216, XP002128207
SANCHEZ A ET AL: "SEQUENCE ANALYSIS OF THE EBOLA VIRUS GENOME: ORGANIZATION, GENETIC ELEMENTS, AND COMPARISON WITH THE GENOME OF MARBURG VIRUS", VIRUS RESEARCH,NL,AMSTERDAM, vol. 29, no. 3, pages 215-240, XP000198438, ISSN: 0168-1702
A. SANCHEZ ET AL.: "Variation in the glycoprotein and VP35 genes of Marburg virus strains", VIROLOGY, vol. 240, no. 1, 5 January 1998 (1998-01-05), ACADEMIC PRESS, INC.,NEW YORK, US, pages 138 - 146, XP002128208
P. PUSHKO ET AL.: "Replicon-helper systems from attenuated Venezuelan equine encephalitis virus: Expression of heterologous genes in vitro and imunization against heterologous pathogens in vivo", VIROLOGY, vol. 239, 1997, ACADEMIC PRESS, INC.,NEW YORK, US, pages 389 - 401, XP002128209
HEVEY M ET AL: "Marburg virus vaccines based upon alphavirus replicons protect guinea pigs and nonhuman primates.", VIROLOGY, (1998 NOV 10) 251 (1) 28-37. JOURNAL CODE: XEA., XP002128210
Download PDF: