Title:
MAREK'S DISEASE VIRUS GENES AND THEIR USE IN VACCINES FOR PROTECTION AGAINST MAREK'S DISEASE
Document Type and Number:
WIPO Patent Application WO1997003187
Kind Code:
A3
Abstract:
A nucleotide sequence encoding the gp82 polypeptide of Marek's disease virus is disclosed. Also disclosed are recombinant viruses which are useful as vaccines for protecting against Marek's Disease, preferably containing two more genes encoding Marek's Disease Virus antigens such as glyprotein B and glycoprotein gp82, under the control of a poxvirus promoter within a region of the DNA of fowlpox virus which is not essential for virus growth. Also provided is a vaccine exhibiting a synergistic immunoprotective effect, comprising a recombinant fowlpox virus expressing Marek's Disease Virus gB protein in combination with turkey herpesvirus. A method of immunizing poultry, comprising administering any of the disclosed vaccines, is also provided.
Inventors:
LEE LUCY F (US)
NAZERIAN KEYVAN (US)
WITTER RICHARD L (US)
WU PING (US)
YANAGIDA NOBORU (US)
YOSHIDA SHIGETO (US)
NAZERIAN KEYVAN (US)
WITTER RICHARD L (US)
WU PING (US)
YANAGIDA NOBORU (US)
YOSHIDA SHIGETO (US)
Application Number:
PCT/US1996/011360
Publication Date:
March 20, 1997
Filing Date:
July 05, 1996
Export Citation:
Assignee:
NIPPON ZEON CO (JP)
US AGRICULTURE (US)
LEE LUCY F (JP)
NAZERIAN KEYVAN (JP)
WITTER RICHARD L (JP)
WU PING (JP)
YANAGIDA NOBORU (JP)
YOSHIDA SHIGETO (JP)
US AGRICULTURE (US)
LEE LUCY F (JP)
NAZERIAN KEYVAN (JP)
WITTER RICHARD L (JP)
WU PING (JP)
YANAGIDA NOBORU (JP)
YOSHIDA SHIGETO (JP)
International Classes:
C12N15/09; A61K39/255; A61K48/00; A61P31/12; C07K14/055; C12N7/00; A61K39/00; (IPC1-7): C12N7/04; C07K14/055; C12N15/86; A61K39/255
Domestic Patent References:
| WO1990002803A2 | 1990-03-22 |
Other References:
NAZERIAN K ET AL: "Protection against Marek's disease by a fowlpox virus recombinant expressing the glycoprotein B of Marek's disease virus.", J VIROL, MAR 1992, 66 (3) P1409-13, UNITED STATES, XP000610082
REDDY SK ET AL: "PROTECTIVE EFFICACY OF A RECOMBINANT HERPESVIRUS OF TURKEYS AS AN IN OVO VACCINE AGAINST NEWCASTLE AND MAREKS DISEASES IN SPECIFIC PATHOGEN-FREE CHICKENS", VACCINE, 1996, 14, 469-477, XP000616405
YANAGIDA N ET AL: "Recombinant fowlpox viruses expressing the glycoprotein B homolog and the pp38 gene of Marek's disease virus.", J VIROL, MAR 1992, 66 (3) P1402-8, UNITED STATES, XP000616407
WITTER RL: "INFLUENCE OF SEROTYPE AND VIRUS-STRAIN ON SYNERGISM BETWEEN MAREKS-DISEASE VACCINE VIRUSES", AVIAN PATHOLOGY, 1992, 21, 601-614, XP000617139
ZELNIK V: "MAREKS-DISEASE AND NEW APPROACHES TO ITS CONTROL", ACTA VIROLOGICA, 1995, 39, 53-63, XP000616411
BOYLE DB ET AL: "Recombinant fowlpox virus vaccines for poultry.", IMMUNOL CELL BIOL, OCT 1993, 71 ( PT 5) P391-7, AUSTRALIA, XP000609353
REDDY SK ET AL: "PROTECTIVE EFFICACY OF A RECOMBINANT HERPESVIRUS OF TURKEYS AS AN IN OVO VACCINE AGAINST NEWCASTLE AND MAREKS DISEASES IN SPECIFIC PATHOGEN-FREE CHICKENS", VACCINE, 1996, 14, 469-477, XP000616405
YANAGIDA N ET AL: "Recombinant fowlpox viruses expressing the glycoprotein B homolog and the pp38 gene of Marek's disease virus.", J VIROL, MAR 1992, 66 (3) P1402-8, UNITED STATES, XP000616407
WITTER RL: "INFLUENCE OF SEROTYPE AND VIRUS-STRAIN ON SYNERGISM BETWEEN MAREKS-DISEASE VACCINE VIRUSES", AVIAN PATHOLOGY, 1992, 21, 601-614, XP000617139
ZELNIK V: "MAREKS-DISEASE AND NEW APPROACHES TO ITS CONTROL", ACTA VIROLOGICA, 1995, 39, 53-63, XP000616411
BOYLE DB ET AL: "Recombinant fowlpox virus vaccines for poultry.", IMMUNOL CELL BIOL, OCT 1993, 71 ( PT 5) P391-7, AUSTRALIA, XP000609353
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