MARKERS FOR PRE-CANCER AND CANCER CELLS AND THE METHOD TO INTERFERE WITH CELL PROLIFERATION THEREIN

WIPO Patent Application WO2005001030

A3

A novel family of human mitochondrial RNAs, referrred to as chimeric RNAs, which are differentially expressed in normal, pre-cancer and cancer cells, are described. Oligonucleotides targeted to the chimeric RNAs are provided. The described oligonucleotides or their analogs can be used for cancer diagnostics and cancer therapy as well as for research. In one embodiment of this invention, these oligonucleotides hybridize with the sense or with the antisense mitochondrial chimeric RNAs, and the result of the hybridization is useful to differentiate between normal proliferating cells, pre-cancer cells and cancer cells. In another embodiment of the invention, the compositions comprise oligonucleotides that hybridize with the human chimeric RNAs resulting in cancer cell and pre-cancer cell death, while there is no effect in normal cells, constituting therrefore, a novel approach for cancer therapy.

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BURZIO LUIS O (CL)
VILLEGAS JAIME E (CL)
BURZIO VERONICA A (CL)

PCT/US2004/015929

December 22, 2005

May 21, 2004

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BIOS CHILE I G S A (CL)
BURZIO LUIS O (CL)
VILLEGAS JAIME E (CL)
BURZIO VERONICA A (CL)

A61K48/00; C07F9/6561; C07H21/04; C12N15/113; C12N; (IPC1-7): C07H21/04; A61K48/00; C12Q1/68

US6503533B1	2003-01-07
US5801154A	1998-09-01
US5998203A	1999-12-07

CAPLEN NJ ET AL: "dsRNA-mediated gene silencing in cultured Drosophila cells: a tissue culture model for the analysis of RNA interference.", GENE., vol. 252, 2000, pages 95 - 105, XP002945262

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