Title:
MATERIALS PRESENTING NOTCH SIGNALING MOLECULES TO CONTROL CELL BEHAVIOR
Document Type and Number:
WIPO Patent Application WO/2012/064697
Kind Code:
A3
Abstract:
The invention provides a solution to the problem of delivering molecules in a physiologically relevant manner to direct cell fate. For example, a Notch ligand molecule is presented in a micro-environment that mimics the environment encountered in vivo. Accordingly, the invention features a cell delivery vehicle comprising a biocompatible hydrogel or polymer and a composition that binds to a Notch receptor and methods of directing cell fate, e.g., stem cell differentiation, using such compositions.
Inventors:
CAO LAN (US)
BOUHARDIR KAMAL H (LB)
MOONEY DAVID J (US)
BOUHARDIR KAMAL H (LB)
MOONEY DAVID J (US)
Application Number:
PCT/US2011/059710
Publication Date:
July 12, 2012
Filing Date:
November 08, 2011
Export Citation:
Assignee:
HARVARD COLLEGE (US)
CAO LAN (US)
BOUHARDIR KAMAL H (LB)
MOONEY DAVID J (US)
CAO LAN (US)
BOUHARDIR KAMAL H (LB)
MOONEY DAVID J (US)
International Classes:
A61K47/48; A61K31/4015; A61K31/7052; A61K31/7056; A61K35/12; A61K38/18; A61K38/28
Domestic Patent References:
| WO2009155583A1 | 2009-12-23 |
Foreign References:
| US20070026518A1 | 2007-02-01 | |||
| US20040242482A1 | 2004-12-02 |
Other References:
MORGAN E. CARLSON ET AL.: "Notch signaling pathway and tissue engineering", FRONTIERS IN BIOSCIENCE, vol. 12, 1 September 2007 (2007-09-01), pages 5143 - 5156
Attorney, Agent or Firm:
BEATTIE, Ingrid A. et al. (P.C.One Finacial Cente, Boston MA, US)
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