Title:
MATRIX METALLOPROTEASE INHIBITOR CONTAINING POLYLACTIC ACID MIXTURE
Document Type and Number:
WIPO Patent Application WO/2005/039599
Kind Code:
A1
Abstract:
It is intended to provide a novel matrix metalloprotease inhibitor by evaluating the matrix metalloprotease inhibitory effect shown by a cyclic and/or chain polylactic acid mixture. Namely, a matrix metalloprotease inhibitor containing a cyclic and/or chain polylactic acid mixture having a degree of condensation of from 3 to 20.
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Inventors:
TAKAHASHI TAKAYUKI (JP)
NAGATO YASUKAZU (JP)
MURAKAMI MASAHIRO (JP)
NAGATO YASUKAZU (JP)
MURAKAMI MASAHIRO (JP)
Application Number:
PCT/JP2004/015871
Publication Date:
May 06, 2005
Filing Date:
October 20, 2004
Export Citation:
Assignee:
AMATO PHARM PROD LTD (JP)
TAKAHASHI TAKAYUKI (JP)
NAGATO YASUKAZU (JP)
MURAKAMI MASAHIRO (JP)
TAKAHASHI TAKAYUKI (JP)
NAGATO YASUKAZU (JP)
MURAKAMI MASAHIRO (JP)
International Classes:
A23L1/30; A61K31/357; A61K31/765; A61P1/02; A61P1/04; A61P1/16; A61P9/00; A61P9/10; A61P11/00; A61P17/00; A61P17/02; A61P19/02; A61P19/04; A61P19/08; A61P19/10; A61P31/18; A61P35/00; A61P35/04; A61P43/00; C07D323/04; (IPC1-7): A61K31/765; A23L1/30; A61P1/02; A61P1/04; A61P1/16; A61P9/00; A61P19/00; A61P35/00
Foreign References:
| JPH10130153A | 1998-05-19 | |||
| JPH09227388A | 1997-09-02 |
Other References:
TANAKA H. ET AL.: "Antitumor efficacy of hypothemycin, a new ras-signaling inhibitor", JPN. J. CANCER RES., vol. 90, 1999, pages 1139 - 1145, XP002983484
SHIMA I. ET AL.: "Production of matrix metalloproteinase-2 and metalloproteinase-3 related to malignant behaviour of Esophageal carcinoma", CANCER, vol. 70, no. 12, 1992, pages 2747 - 2753, XP002983485
THOMASSET N. ET AL.: "Expression of autoactivated stromelysin-1 in mammary glands of transgenic mice leads to a reactive stroma during early development", AMERICAN JOURNAL OF PATHOLOGY, vol. 153, no. 2, 1998, pages 457 - 467, XP002983486
SHIMA I. ET AL.: "Production of matrix metalloproteinase-2 and metalloproteinase-3 related to malignant behaviour of Esophageal carcinoma", CANCER, vol. 70, no. 12, 1992, pages 2747 - 2753, XP002983485
THOMASSET N. ET AL.: "Expression of autoactivated stromelysin-1 in mammary glands of transgenic mice leads to a reactive stroma during early development", AMERICAN JOURNAL OF PATHOLOGY, vol. 153, no. 2, 1998, pages 457 - 467, XP002983486
Attorney, Agent or Firm:
SIKS & CO. (Kyobashi-Nisshoku Bldg. 8-7, Kyobashi 1-chom, Chuo-ku Tokyo 31, JP)
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