MATRIX TYPE PATCH PREPARATION - HISAMITSU PHARMACEUTICAL CO

Title:

MATRIX TYPE PATCH PREPARATION

Document Type and Number:

WIPO Patent Application WO/1996/016642

Kind Code:

A1

Abstract:

A matrix type patch preparation having a pressure-sensitive adhesive layer comprising a physiologically active substance, organic acid, hydrophobic polymer, tackifier resin, plasticizer and sorbefacient preferably in the proportion of 0.1-20 wt.%, 0.01-15 wt.%, 15-60 wt.%, 10-70 wt.%, 10-60 wt.% and 0.01-20 wt.%, respectively. Preferable examples of the organic acid are aliphatic carboxylic acids, aromatic carboxylic acids, alkylsulfonic acids, alkylsulfonic acid derivatives, cholic acid derivatives, and water-soluble inorganic salts thereof. This preparation serves to enhance percutaneous absorbability of the physiologically active substance and is extremely reduced in skin irritation.

Inventors:

HIGO NARUHITO (JP)
KOMORI KEN-ICHI (JP)
TERAHARA TAKAAKI (JP)

Application Number:

PCT/JP1995/001073

Publication Date:

June 06, 1996

Filing Date:

June 01, 1995

Export Citation:

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Assignee:

HISAMITSU PHARMACEUTICAL CO (JP)
HIGO NARUHITO (JP)
KOMORI KEN ICHI (JP)
TERAHARA TAKAAKI (JP)

International Classes:

A61K9/70; A61K9/06; A61K31/445; A61K47/12; A61P17/00; A61P27/16; A61P37/08; A61P43/00; (IPC1-7): A61K9/70

Foreign References:

JPH02300118A	1990-12-12
JPH01290630A	1989-11-22
JPS56140916A	1981-11-04
JPS61186317A	1986-08-20

Other References: